PMID- 20217189
OWN - NLM
STAT- MEDLINE
DCOM- 20100910
LR  - 20181113
IS  - 1573-4838 (Electronic)
IS  - 0957-4530 (Linking)
VI  - 21
IP  - 6
DP  - 2010 Jun
TI  - The pH-induced thermosensitive poly (NIPAAm-co-AAc-co-HEMA)-g-PCL micelles used 
      as a drug carrier.
PG  - 1881-90
LID - 10.1007/s10856-010-4049-x [doi]
AB  - The macromonomer of 2-hydroxyethyl methyacrylate-caprolactone (HPCL) was 
      synthesized by the ring-opening polymerization (ROP) of epsilon-caprolactone, 
      which was initiated by 2-hydroxyethyl methyacrylate (HEMA). Then, the graft 
      terpolymers of NIPAAm-co-AAc-co-HEMA-g-PCL (PHNA-CL) with varying mole ratios 
      were subsequently synthesized by free radical polymerization of HEMA-PCL, 
      N-isopropylacrylamide (NIPAAm) and acrylic acid (AAc). PHNA-CL was further 
      self-assembled in different types of solvent. All the as-prepared copolymers were 
      characterized by 1H NMR, FT-IR and GPC. Micellization behaviors of micelles were 
      studied by TEM and DLS. The micelles exhibited a phase transition temperature 
      which can be readily adjusted by changing pH value of the micellization system. 
      Micelle loaded with doxorubicin (DOX) was used to evaluate the drug release 
      behavior. The release of DOX from micelles could be controlled by changing pH 
      value and temperature in buffer solutions. The micelles are potentially to be 
      used as a new anticancer drug carrier for intracellular delivery.
FAU - Dai, Weifeng
AU  - Dai W
AD  - Key Laboratory for Ultrafine Materials of Ministry of Education, School of 
      Materials Science and Engineering, East China University of Science and 
      Technology, P.O. Box 391, 130 Meilong Road, 200237 Shanghai, People's Republic of 
      China.
FAU - Zhang, Yan
AU  - Zhang Y
FAU - Du, Zhengzhen
AU  - Du Z
FAU - Ru, Minliang
AU  - Ru M
FAU - Lang, Meidong
AU  - Lang M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100310
PL  - United States
TA  - J Mater Sci Mater Med
JT  - Journal of materials science. Materials in medicine
JID - 9013087
RN  - 0 (Acrylamides)
RN  - 0 (Caproates)
RN  - 0 (Drug Carriers)
RN  - 0 (Lactones)
RN  - 0 (Micelles)
RN  - 0 (Polymers)
RN  - 0 (Solutions)
RN  - 56RE988L1R (caprolactone)
RN  - 80168379AG (Doxorubicin)
RN  - B7GFF17L9U (N-isopropylacrylamide)
SB  - IM
MH  - Acrylamides
MH  - Caproates
MH  - Doxorubicin/chemistry
MH  - Drug Carriers/*chemistry
MH  - Lactones
MH  - *Micelles
MH  - Polymers/chemistry
MH  - Solutions
MH  - Temperature
EDAT- 2010/03/11 06:00
MHDA- 2010/09/11 06:00
CRDT- 2010/03/11 06:00
PHST- 2009/12/21 00:00 [received]
PHST- 2010/03/01 00:00 [accepted]
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/09/11 06:00 [medline]
AID - 10.1007/s10856-010-4049-x [doi]
PST - ppublish
SO  - J Mater Sci Mater Med. 2010 Jun;21(6):1881-90. doi: 10.1007/s10856-010-4049-x. 
      Epub 2010 Mar 10.