PMID- 20217540
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20100310
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
IP  - 197
DP  - 2010
TI  - Medical devices for the treatment of eye diseases.
PG  - 469-89
LID - 10.1007/978-3-642-00477-3_16 [doi]
AB  - Development of intraocular drug delivery systems (DDSs) is urgently required for 
      the treatment of eye diseases, especially in the posterior segment of the eye 
      (the vitreous cavity, retina, and choroid), most of which are refractory to 
      conventional pharmacologic approaches; eye drops and systemically administered 
      drugs cannot achieve therapeutic drug concentrations in the posterior segment of 
      the eye. Repeated intravitreal injections of anti-angiogenic agents are effective 
      in the treatment of age-related macular degeneration, but there remain risks of 
      serious side effects such as endophthalmitis associated with repeated injections. 
      Intraocular DDSs may address these problems. Intraocular sustained drug release 
      from implantable or injectable devices has been investigated to treat 
      vitreoretinal diseases. A reservoir-type nonbiodegradable implant was first 
      launched in the market in 1996 for the treatment of cytomegalovirus retinitis 
      secondary to the acquired immunodeficiency syndrome, followed by clinical trials 
      for a variety of potent devices to treat other challenging eye diseases. An 
      injectable rod-shaped insert releasing a steroid is presently being assessed in a 
      phase III trial to treat macular edema secondary to diabetic retinopathy or 
      retinal vein occlusion. Thus various types of intraocular DDSs will be 
      commercially available to treat vision-threatening intraocular diseases in the 
      near future.
FAU - Yasukawa, Tsutomu
AU  - Yasukawa T
AD  - Department of Ophthalmology and Visual Science, Nagoya City University Graduate 
      School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 
      467-8601, Japan. yasukawa@med.nagoya-cu.ac.jp
FAU - Ogura, Yuichiro
AU  - Ogura Y
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Drug Implants)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Administration, Topical
MH  - Delayed-Action Preparations
MH  - *Drug Delivery Systems
MH  - Drug Implants
MH  - Equipment and Supplies
MH  - Eye Diseases/*drug therapy
MH  - Humans
MH  - Pharmaceutical Preparations/*administration & dosage
MH  - Technology, Pharmaceutical/methods
RF  - 63
EDAT- 2010/03/11 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/03/11 06:00
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - 10.1007/978-3-642-00477-3_16 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2010;(197):469-89. doi: 10.1007/978-3-642-00477-3_16.