PMID- 20219018
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20181201
IS  - 1600-0404 (Electronic)
IS  - 0001-6314 (Linking)
VI  - 123
IP  - 1
DP  - 2011 Jan
TI  - A pilot study of topiramate in childhood absence epilepsy.
PG  - 54-9
LID - 10.1111/j.1600-0404.2010.01347.x [doi]
AB  - OBJECTIVE: Evaluate the antiepileptic effect of topiramate monotherapy in 
      childhood absence epilepsy (CAE). MATERIALS AND METHODS: Childhood absence 
      epilepsy patients aged 4-9 years were initiated with topiramate 15 or 25 mg/day, 
      which was titrated upwards until patients were free of absence seizures. The 
      primary efficacy outcome was seizure-free rates after a 12-week maintenance 
      period. RESULTS: The study was terminated early due to lack of efficacy after 
      enrollment of 12 patients. Four patients completed the study; two became 
      clinically seizure-free, but without a significant reduction in the number of 
      electrographic seizures. Six patients discontinued for lack of efficacy, none due 
      to adverse events (AEs). Mean reduction in seizure count was seen on Days 22 (P = 
      0.0391) and 36 (P = 0.0156) and percentage of days with seizures decreased from 
      baseline. Most AEs were mild. CONCLUSIONS: Although well-tolerated, this pilot 
      study did not demonstrate an antiepileptic effect of topiramate monotherapy for 
      treatment of CAE.
CI  - Copyright (c) 2010 The Authors. Journal compilation (c) 2010 Blackwell Munksgaard.
FAU - Pina-Garza, J E
AU  - Pina-Garza JE
AD  - Vanderbilt University Medical Center, Nashville, TN, USA.
FAU - Schwarzman, L
AU  - Schwarzman L
FAU - Wiegand, F
AU  - Wiegand F
FAU - Hulihan, J
AU  - Hulihan J
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (Anticonvulsants)
RN  - 0H73WJJ391 (Topiramate)
RN  - 30237-26-4 (Fructose)
SB  - IM
MH  - Anticonvulsants/*therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Drug Evaluation
MH  - Epilepsy, Absence/*drug therapy
MH  - Female
MH  - Fructose/*analogs & derivatives/therapeutic use
MH  - Humans
MH  - Male
MH  - Pilot Projects
MH  - Time Factors
MH  - Topiramate
EDAT- 2010/03/12 06:00
MHDA- 2011/03/24 06:00
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - ANE1347 [pii]
AID - 10.1111/j.1600-0404.2010.01347.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2011 Jan;123(1):54-9. doi: 10.1111/j.1600-0404.2010.01347.x.