PMID- 20219880
OWN - NLM
STAT- MEDLINE
DCOM- 20100720
LR  - 20181113
IS  - 1556-679X (Electronic)
IS  - 1556-6811 (Print)
IS  - 1556-679X (Linking)
VI  - 17
IP  - 5
DP  - 2010 May
TI  - Pilot study of whole-blood gamma interferon response to the Vibrio cholerae toxin 
      B subunit and resistance to enterotoxigenic Escherichia coli-associated diarrhea.
PG  - 879-81
LID - 10.1128/CVI.00486-09 [doi]
AB  - Enterotoxigenic Escherichia coli (ETEC), which produces heat-labile toxin (LT), 
      is a common cause of travelers' diarrhea (TD). The B subunit of ETEC LT is 
      immunologically related to the B subunit of Vibrio cholerae toxin (CT). In this 
      pilot study we evaluated the whole-blood gamma interferon response to CT B in 17 
      U.S. adults traveling to Mexico. Only one of nine subjects who demonstrated a 
      cellular immune response as determined by whole-blood gamma interferon production 
      to CT B on arrival to Mexico developed diarrhea, whereas five of eight without a 
      cellular response developed diarrhea. Markers of the cellular immune response to 
      ETEC LT could help in identifying individuals immune to ETEC LT, and these 
      markers deserve additional study.
FAU - Flores, Jose
AU  - Flores J
AD  - Center for Infectious Diseases, School of Public Health, University of Texas at 
      Houston, Houston, Texas, USA.
FAU - DuPont, Herbert L
AU  - DuPont HL
FAU - Paredes-Paredes, Mercedes
AU  - Paredes-Paredes M
FAU - Aguirre-Garcia, M Magdalena
AU  - Aguirre-Garcia MM
FAU - Rojas, Araceli
AU  - Rojas A
FAU - Gonzalez, Alexei
AU  - Gonzalez A
FAU - Okhuysen, Pablo C
AU  - Okhuysen PC
LA  - eng
GR  - R01 AI54948-01/AI/NIAID NIH HHS/United States
GR  - P30 DK056338/DK/NIDDK NIH HHS/United States
GR  - DK56338/DK/NIDDK NIH HHS/United States
GR  - R01 AI054948-05/AI/NIAID NIH HHS/United States
GR  - R01 AI054948/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100310
PL  - United States
TA  - Clin Vaccine Immunol
JT  - Clinical and vaccine immunology : CVI
JID - 101252125
RN  - 0 (Biomarkers)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9012-63-9 (Cholera Toxin)
SB  - IM
MH  - Adult
MH  - Biomarkers
MH  - Blood/*immunology
MH  - Cells, Cultured
MH  - Cholera Toxin/*immunology
MH  - Diarrhea/immunology/*prevention & control
MH  - Enterotoxigenic Escherichia coli/*immunology
MH  - Escherichia coli Infections/immunology/*prevention & control
MH  - Female
MH  - Humans
MH  - *Immunity, Innate
MH  - Interferon-gamma/*blood
MH  - Leukocytes, Mononuclear
MH  - Male
MH  - Mexico
MH  - Pilot Projects
MH  - Travel
MH  - United States
PMC - PMC2863377
EDAT- 2010/03/12 06:00
MHDA- 2010/07/21 06:00
PMCR- 2010/11/01
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/07/21 06:00 [medline]
PHST- 2010/11/01 00:00 [pmc-release]
AID - CVI.00486-09 [pii]
AID - 0486-09 [pii]
AID - 10.1128/CVI.00486-09 [doi]
PST - ppublish
SO  - Clin Vaccine Immunol. 2010 May;17(5):879-81. doi: 10.1128/CVI.00486-09. Epub 2010 
      Mar 10.