PMID- 20221274
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20200930
IS  - 2093-3827 (Electronic)
IS  - 1226-4512 (Print)
IS  - 1226-4512 (Linking)
VI  - 14
IP  - 1
DP  - 2010 Feb
TI  - Dendritic Cells-based Vaccine and Immune Monitoring for Hepatocellular Carcinoma.
PG  - 11-4
LID - 10.4196/kjpp.2010.14.1.11 [doi]
AB  - Human tumors, including those of the hepatobiliary system, express a number of 
      specific antigens that can be recognized by T cells, and may provide potential 
      targets for cancer immunotherapy. Dendritic cells (DCs) are rare leucocytes that 
      are uniquely potent in their ability to capture, process and present antigens to 
      T cells. The ability to culture sufficient numbers of DCs from human bone marrow 
      or blood progenitors has attracted a great deal of interest in their potential 
      utilization in human tumor vaccination. CD34(+) peripheral blood stem cells 
      (PBSCs) were obtained from a patient with a hepatocellular carcinoma. The PBSCs 
      were cultured in the X-VIVO 20 medium supplemented with the Flt-3 Ligand (FL), 
      GM-CSF, IL-4 and TNF-alpha for 12 days. The morphology and functions of the cells 
      were examined. The generated cells had the typical morphology of DCs. When the 
      DCs were reinjected into the same patient, an augmentation of the cytotoxic T 
      lymphocyte (CTL) activity was observed. Concomitantly, an increase in the natural 
      killer (NK) cell activity was also detected in the patient. These results suggest 
      that DCs-based cancer immunotherapy may become an important treatment option for 
      cancer patients in the future.
FAU - Lee, Dae-Heui
AU  - Lee DH
AD  - Department of Pharmacology, Kosin University College of Medicine, Busan 602-703, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20100228
PL  - Korea (South)
TA  - Korean J Physiol Pharmacol
JT  - The Korean journal of physiology & pharmacology : official journal of the Korean 
      Physiological Society and the Korean Society of Pharmacology
JID - 9709505
PMC - PMC2835977
OTO - NOTNLM
OT  - Cancer immunotherapy
OT  - Dendritic cells (DCs)
OT  - Hepatocellular carcinoma
OT  - Natural killer (NK) cells
OT  - Peripheral blood stem cells (PBSCs)
EDAT- 2010/03/12 06:00
MHDA- 2010/03/12 06:01
PMCR- 2010/02/01
CRDT- 2010/03/12 06:00
PHST- 2009/12/02 00:00 [received]
PHST- 2010/01/31 00:00 [revised]
PHST- 2010/02/12 00:00 [accepted]
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/03/12 06:01 [medline]
PHST- 2010/02/01 00:00 [pmc-release]
AID - 10.4196/kjpp.2010.14.1.11 [doi]
PST - ppublish
SO  - Korean J Physiol Pharmacol. 2010 Feb;14(1):11-4. doi: 10.4196/kjpp.2010.14.1.11. 
      Epub 2010 Feb 28.