PMID- 20221326 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20110714 LR - 20240419 IS - 1052-1372 (Print) IS - 1052-1372 (Linking) VI - 35 IP - 2 DP - 2010 Feb TI - Pharmacological and clinical differences between low-molecular-weight heparins: implications for prescribing practice and therapeutic interchange. PG - 95-105 AB - Thanks to their predictable pharmacokinetics and ease of use, low-molecular-weight heparins (LMWHs) have established uses in the prevention and treatment of thrombotic diseases and as a replacement for unfractionated heparin (UFH). Although LMWHs as a class have similar antithrombotic effects, they comprise a diverse group of agents with distinct biochemical and pharmacological profiles. In light of the ongoing pressure to contain pharmacy costs, the diversity among the LMWHs and their benefits over UFH are important considerations in clinical practice. FAU - Merli, Geno J AU - Merli GJ FAU - Groce, James B AU - Groce JB LA - eng PT - Journal Article PL - United States TA - P T JT - P & T : a peer-reviewed journal for formulary management JID - 9015516 PMC - PMC2827912 OTO - NOTNLM OT - biosimilars OT - low-molecular-weight heparins OT - therapeutic equivalence OT - therapeutic interchange EDAT- 2010/03/12 06:00 MHDA- 2010/03/12 06:01 PMCR- 2010/03/01 CRDT- 2010/03/12 06:00 PHST- 2009/10/27 00:00 [accepted] PHST- 2010/03/12 06:00 [entrez] PHST- 2010/03/12 06:00 [pubmed] PHST- 2010/03/12 06:01 [medline] PHST- 2010/03/01 00:00 [pmc-release] AID - ptj35_2095 [pii] PST - ppublish SO - P T. 2010 Feb;35(2):95-105.