PMID- 20221615
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20181113
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 99
IP  - 8
DP  - 2010 Aug
TI  - Effects of the main green tea polyphenol epigallocatechin-3-gallate on cardiac 
      involvement in patients with AL amyloidosis.
PG  - 483-90
LID - 10.1007/s00392-010-0142-x [doi]
AB  - BACKGROUND: Amyloid light chain (AL) amyloidosis is a rare disease with poor 
      prognosis and limited therapeutic alternatives. Recently, one clinical case with 
      cardiac involvement, as well as a compelling evidence of green tea polyphenol, 
      epigallocatechin-3-gallate (EGCG), inducing the formation of benign aggregation 
      products that do not polymerize into fibrils were published. This is a report of 
      the cardiac effects of green tea consumption in these patients. METHODS: Patients 
      with known cardiac involvement in AL amyloidosis were examined by routine 
      cardiovascular examinations that took place every 3-6 months. Of 59 patients with 
      cardiac involvement, 11 revealed a decrease of at least 2 mm of interventricular 
      wall thickness, after initiation of regular green tea consumption (GT). A matched 
      historic control group (n = 22) was selected. Comprehensive echocardiography was 
      conducted at every control examination and analyzed offline by two independent 
      examiners. RESULTS: GT patients showed an improvement in New York Heart 
      Association (NYHA) class from a median of 3 (25th, 75th percentiles: 2, 3) to 2 
      (2, 3), P = 0.038. Septal thickness decreased from 18 (18, 20) to 16 (16, 17) mm, 
      P = 0.021. Left ventricular mass index decreased from 175 (154, 180) to 133 (128, 
      154) g/m(2), P = 0.007. Comparing both groups, an increase in left ventricular 
      ejection fraction could be found in the GT group, 65 (51, 73) versus 53 (47, 
      59)%, P = 0.012. These changes could not be observed in the control group. 
      CONCLUSION: Consumption of green tea polyphenol EGCG in patients with cardiac 
      involvement with AL amyloidosis causes a significant decrease in left ventricular 
      wall thickness and mass, as well as an improvement in NYHA functional 
      classification and left ventricular ejection fraction.
FAU - Mereles, Derliz
AU  - Mereles D
AD  - Department of Internal Medicine III, University of Heidelberg, Germany. 
      derliz.mereles@med.uni-heidelberg.de
FAU - Buss, Sebastian J
AU  - Buss SJ
FAU - Hardt, Stefan E
AU  - Hardt SE
FAU - Hunstein, Werner
AU  - Hunstein W
FAU - Katus, Hugo A
AU  - Katus HA
LA  - eng
PT  - Journal Article
DEP - 20100310
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
RN  - 0 (Plant Extracts)
RN  - 0 (Tea)
RN  - 8R1V1STN48 (Catechin)
RN  - BQM438CTEL (epigallocatechin gallate)
SB  - IM
MH  - Aged
MH  - Amyloidosis/*complications/diagnosis/*diet therapy
MH  - Catechin/*analogs & derivatives/therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Plant Extracts/*therapeutic use
MH  - Tea/*chemistry
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/diagnosis/*etiology/*prevention & control
EDAT- 2010/03/12 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/03/12 06:00
PHST- 2009/11/01 00:00 [received]
PHST- 2010/02/23 00:00 [accepted]
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - 10.1007/s00392-010-0142-x [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2010 Aug;99(8):483-90. doi: 10.1007/s00392-010-0142-x. Epub 
      2010 Mar 10.