PMID- 20223708
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20161125
IS  - 1878-5506 (Electronic)
IS  - 1389-9457 (Linking)
VI  - 11
IP  - 4
DP  - 2010 Apr
TI  - Relevance of substantia nigra hyperechogenicity and reduced odor identification 
      in idiopathic REM sleep behavior disorder.
PG  - 361-5
LID - 10.1016/j.sleep.2009.12.006 [doi]
AB  - BACKGROUND: Substantia nigra (SN) hyperechogenicity determined by transcranial 
      sonography (TCS) and olfactory dysfunction are common findings in Parkinson 
      disease (PD), which may reveal a prodromal synucleinopathy in idiopathic REM 
      sleep behavior disorder (iRBD). METHODS: TCS and the Odor Stick Identification 
      Test for Japanese (OSIT-J) were performed in 34 consecutive patients with iRBD 
      (67.9+/-6.1years), 17 consecutive patients with PD (66.4+/-6.7years), and 21 
      control group subjects (64.4+/-5.8years). RESULTS: There was a significantly 
      increased area of echogenicity in the SN in the iRBD group (0.20+/-0.13cm2) and 
      PD group (0.22+/-0.11cm2) compared with the control group (0.06+/-0.06cm(2)). We 
      found pathological SN hyperechogenicity (0.20cm2) in 41.2% of the iRBD group, 
      52.6% of the PD group, and 9.5% of the control group. Further, there were 
      abnormal findings of both pathological SN hyperechogenicity (0.20cm2) and 
      functional anosmia or hyposmia in 4 (11.8%) or 9 (26.5%) of the iRBD group 
      subjects, respectively, and 7 (57.9%) or 2 (11.8%) of the PD group subjects, 
      respectively. CONCLUSION: Pathological SN hyperechogenic abnormality and 
      functional anosmia in iRBD may be a disease state in the transition to a 
      neurodegenerative disease.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Iwanami, Masaoki
AU  - Iwanami M
AD  - Department of Neurology, Center of Sleep Medicine, Dokkyo Medical University 
      School of Medicine, Japan.
FAU - Miyamoto, Tomoyuki
AU  - Miyamoto T
FAU - Miyamoto, Masayuki
AU  - Miyamoto M
FAU - Hirata, Koichi
AU  - Hirata K
FAU - Takada, Etsuo
AU  - Takada E
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Sleep Med
JT  - Sleep medicine
JID - 100898759
SB  - IM
CIN - Sleep Med. 2010 Apr;11(4):339-40. PMID: 20226731
MH  - Aged
MH  - Arousal/*physiology
MH  - *Electroencephalography
MH  - Female
MH  - Humans
MH  - Male
MH  - Neurodegenerative Diseases/epidemiology
MH  - *Odorants
MH  - Olfaction Disorders/*diagnosis/*epidemiology
MH  - REM Sleep Behavior Disorder/*diagnosis/*epidemiology
MH  - Substantia Nigra/*physiopathology
EDAT- 2010/03/13 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/03/13 06:00
PHST- 2009/10/05 00:00 [received]
PHST- 2009/11/28 00:00 [revised]
PHST- 2009/12/04 00:00 [accepted]
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - S1389-9457(10)00054-7 [pii]
AID - 10.1016/j.sleep.2009.12.006 [doi]
PST - ppublish
SO  - Sleep Med. 2010 Apr;11(4):361-5. doi: 10.1016/j.sleep.2009.12.006.