PMID- 20224759
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20181113
IS  - 1110-7251 (Electronic)
IS  - 1110-7243 (Print)
IS  - 1110-7243 (Linking)
VI  - 2010
DP  - 2010
TI  - Dendritic cells in the gut: interaction with intestinal helminths.
PG  - 250563
LID - 10.1155/2010/250563 [doi]
LID - 250563
AB  - The mucosal environment in mammals is highly tolerogenic; however, after exposure 
      to pathogens or danger signals, it is able to shift towards an inflammatory 
      response. Dendritic cells (DCs) orchestrate immune responses and are highly 
      responsible, through the secretion of cytokines and expression of surface 
      markers, for the outcome of such immune response. In particular, the DC subsets 
      found in the intestine have specialized functions and interact with different 
      immune as well as nonimmune cells. Intestinal helminths primarily induce Th2 
      responses where DCs have an important yet not completely understood role. In 
      addition, this cross-talk results in the induction of regulatory T cells (T regs) 
      as a result of the homeostatic mucosal environment. This review highlights the 
      importance of studying the particular relation "helminth-DC-milieu" in view of 
      the significance that each of these factors plays. Elucidating the mechanisms 
      that trigger Th2 responses may provide the understanding of how we might modulate 
      inflammatory processes.
FAU - Mendlovic, Fela
AU  - Mendlovic F
AD  - Departamento de Microbiologia y Parasitologia, Facultad de Medicina, Universidad 
      Nacional Autonoma de Mexico (UNAM), Avenue Universidad 3000, Colonia Copilco 
      Universidad, Mexico DF 04510, Mexico.
FAU - Flisser, Ana
AU  - Flisser A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100309
PL  - United States
TA  - J Biomed Biotechnol
JT  - Journal of biomedicine & biotechnology
JID - 101135740
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Helminths/*immunology/*pathogenicity
MH  - Humans
MH  - Intestinal Diseases, Parasitic/*immunology/*parasitology/pathology
MH  - Intestines/*immunology/*parasitology/pathology
MH  - Models, Immunological
PMC - PMC2836138
EDAT- 2010/03/13 06:00
MHDA- 2010/06/17 06:00
PMCR- 2010/03/09
CRDT- 2010/03/13 06:00
PHST- 2009/08/22 00:00 [received]
PHST- 2009/11/30 00:00 [revised]
PHST- 2009/12/18 00:00 [accepted]
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
PHST- 2010/03/09 00:00 [pmc-release]
AID - 10.1155/2010/250563 [doi]
PST - ppublish
SO  - J Biomed Biotechnol. 2010;2010:250563. doi: 10.1155/2010/250563. Epub 2010 Mar 9.