PMID- 20225043
OWN - NLM
STAT- MEDLINE
DCOM- 20100624
LR  - 20100312
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 614
DP  - 2010
TI  - Lentiviral vector transduction of dendritic cells for novel vaccine strategies.
PG  - 161-71
LID - 10.1007/978-1-60761-533-0_11 [doi]
AB  - Dendritic cells (DCs) are key antigen-presenting cells that induce primary and 
      memory immune response. Patients with chronic infections or cancer often display 
      DC dysfunctions. Modification of DCs or DC progenitors in vitro may overcome the 
      problems with defective DCs in vivo. Lentiviral vector is highly efficient in 
      transducing hematopoietic cells including DCs. Examples of lentiviral 
      modification of DCs with immune modulatory genes and analysis of antigen-specific 
      T cells to demonstrate enhanced immune effector functions of DCs will be 
      introduced.
FAU - Chang, Lung-Ji
AU  - Chang LJ
AD  - Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center and 
      McKnight Brain Institute, College of Medicine, University of Florida, 
      Gainesville, FL, USA. lchang@college.med.ufl.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Vaccines)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - *Genetic Vectors
MH  - Humans
MH  - Lentivirus/*genetics
MH  - *Transduction, Genetic
MH  - Vaccines/*immunology
EDAT- 2010/03/13 06:00
MHDA- 2010/06/25 06:00
CRDT- 2010/03/13 06:00
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/06/25 06:00 [medline]
AID - 10.1007/978-1-60761-533-0_11 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2010;614:161-71. doi: 10.1007/978-1-60761-533-0_11.