PMID- 20226770
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20131121
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1329
DP  - 2010 May 6
TI  - Minocycline treatment reduces white matter damage after excitotoxic striatal 
      injury.
PG  - 182-93
LID - 10.1016/j.brainres.2010.03.007 [doi]
AB  - We investigated the protective effects of minocycline following white matter 
      damage (WMD) in the rat striatum. Excitotoxic lesions were induced by 
      N-Methyl-d-Aspartate (NMDA) microinjections and caused striatal damage, 
      concomitant with microglial/macrophage activation. The excitotoxic lesion both 
      damaged oligodendrocytes (Tau-1(+) cells) and caused a decrease in tissue 
      reactivity for myelin basic protein (MBP) after post-lesional day 3 (PLD). 
      Treatment with the semi-synthetic tetracycline antibiotic minocycline, however, 
      led to oligodendrocyte preservation and decreased myelin impairment. Taken 
      together, these results suggest that white matter damage (WMD) is an important 
      component of the physiopathology of acute striatal damage and that 
      microglial/macrophage activation contributes to this pathological phenomenon.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Guimaraes, Joanilson S
AU  - Guimaraes JS
AD  - Edmond and Lily Safra International Institute of Neuroscience of Natal, Natal/RN, 
      Brazil.
FAU - Freire, Marco Aurelio M
AU  - Freire MA
FAU - Lima, Rafael R
AU  - Lima RR
FAU - Picanco-Diniz, Cristovam W
AU  - Picanco-Diniz CW
FAU - Pereira, Antonio
AU  - Pereira A
FAU - Gomes-Leal, Walace
AU  - Gomes-Leal W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100311
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Myelin Basic Protein)
RN  - 0 (tau-1 monoclonal antibody)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - FYY3R43WGO (Minocycline)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/administration & dosage/*pharmacology
MH  - Antibodies, Monoclonal/metabolism
MH  - Brain/*drug effects/immunology
MH  - Corpus Striatum/*drug effects/pathology
MH  - Disease Models, Animal
MH  - Macrophage Activation/drug effects/immunology
MH  - Male
MH  - Microglia/drug effects/immunology
MH  - Microinjections
MH  - Minocycline/administration & dosage/*pharmacology
MH  - Myelin Basic Protein/metabolism
MH  - N-Methylaspartate
MH  - Oligodendroglia/*drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
EDAT- 2010/03/17 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/03/16 06:00
PHST- 2009/10/05 00:00 [received]
PHST- 2010/03/01 00:00 [revised]
PHST- 2010/03/03 00:00 [accepted]
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S0006-8993(10)00531-7 [pii]
AID - 10.1016/j.brainres.2010.03.007 [doi]
PST - ppublish
SO  - Brain Res. 2010 May 6;1329:182-93. doi: 10.1016/j.brainres.2010.03.007. Epub 2010 
      Mar 11.