PMID- 2022711
OWN - NLM
STAT- MEDLINE
DCOM- 19910606
LR  - 20131121
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 72
IP  - 5
DP  - 1991 May
TI  - A study of the serum concentration of tumor necrosis factor-alpha in thyroidal 
      and nonthyroidal illnesses.
PG  - 1113-6
AB  - We have studied serum concentrations of immunoassayable tumor necrosis 
      factor-alpha (TNF alpha) and iodothyronines (T4, T3, and rT3) in normal subjects 
      (n = 16) and patients with nonthyroidal illnesses (NTI; n = 13), hyperthyroidism 
      (n = 10), and hypothyroidism (n = 9). The mean (+/- SEM; femtomoles per mL) serum 
      concentration of TNF alpha was 45 +/- 4.3 in normal subjects, 84 +/- 38 in NTI, 
      54 +/- 6.0 in hyperthyroidism, and 50 +/- 10 in hypothyroidism; the various 
      values did not differ significantly from one another. Serum TNF alpha was well 
      within the normal range in all NTI patients, except one patient with a brain 
      glioma and infection in whom it was elevated (540 fmol/mL). There was no 
      significant correlation between serum TNF alpha and serum T4, T3, or rT3 levels 
      in NTI patients. Similarly, there was no correlation between serum TNF alpha and 
      serum thyroid hormone (T3 or T4) levels when data in normal subjects were 
      combined with those in NTI patients. The dialyzable fraction of T3 and the free 
      T3 concentration did not correlate with serum TNF alpha levels. However, there 
      was a tendency toward a positive correlation between dialyzable fraction of T4 
      and the serum concentration of TNF alpha in NTI (r = 0.54; n = 11; 0.05 greater 
      than P less than 0.1). The relationship between these two parameters became more 
      clear when data in normal subjects and NTI patients were combined for statistical 
      analysis (r = 0.59; n = 22; P less than 0.005). The free T4 concentration 
      correlated positively with serum TNF alpha levels whether the data in NTI 
      patients were analyzed alone (r = 0.93; P less than 0.001) or in combination with 
      data from normal subjects (r = 0.85; P less than 0.001). Our data suggest that 
      circulating TNF alpha may contribute to elevated free T4 in NTI. However, it is 
      not a universal or common factor in the pathogenesis of other alterations in 
      serum thyroid hormone levels in NTI (euthyroid sickness syndrome).
FAU - Chopra, I J
AU  - Chopra IJ
AD  - Department of Medicine, University of California School of Medicine, Los Angeles 
      90024.
FAU - Sakane, S
AU  - Sakane S
FAU - Teco, G N
AU  - Teco GN
LA  - eng
GR  - DK-16155/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Euthyroid Sick Syndromes/blood/physiopathology
MH  - Humans
MH  - Hyperthyroidism/blood
MH  - Hypothyroidism/blood
MH  - Middle Aged
MH  - Thyroid Diseases/*blood/physiopathology
MH  - Thyrotropin/blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
MH  - Tumor Necrosis Factor-alpha/*analysis/physiology
EDAT- 1991/05/01 00:00
MHDA- 1991/05/01 00:01
CRDT- 1991/05/01 00:00
PHST- 1991/05/01 00:00 [pubmed]
PHST- 1991/05/01 00:01 [medline]
PHST- 1991/05/01 00:00 [entrez]
AID - 10.1210/jcem-72-5-1113 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1991 May;72(5):1113-6. doi: 10.1210/jcem-72-5-1113.