PMID- 20227221
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20191210
IS  - 1879-0070 (Electronic)
IS  - 0732-8893 (Linking)
VI  - 67
IP  - 1
DP  - 2010 May
TI  - Evaluation of a new third-generation ARCHITECT rHTLV-I/II assay for blood 
      screening and diagnosis.
PG  - 61-9
LID - 10.1016/j.diagmicrobio.2009.12.021 [doi]
AB  - In comparison to current on-market assays, the ARCHITECT rHTLV-I/II assay is the 
      first fully automated assay that simultaneously detects human T-cell lymphotropic 
      virus type I (HTLV-I) and type II (HTLV-II) in human serum and plasma. 
      Specificity was assessed on 5646 blood donors and 692 clinical specimens. For 
      sensitivity determination, 301 HTLV-I-positive and 105 HTLV-II-positive specimens 
      were tested. Precision was between 3.98% and 4.31% coefficient of variation (CV) 
      for specimens with 1 to 6 sample to cutoff. Specificity was 99.95% and 99.86% on 
      specimens from blood donors and hospitalized patients, respectively. Sensitivity 
      evaluation showed 100% detection on 301 HTLV-I and 105 HTLV-II specimens. HTLV-I 
      and HTLV-II viruses are still circulating among general populations even in the 
      low prevalence areas. To control the further spread of these retroviruses, we 
      need to know that it is important to continue screening of blood. The performance 
      evaluation data from this study demonstrate that the high throughput and fully 
      automated ARCHITECT rHTLV-I/II chemiluminescence immunoassay effectively serves 
      this purpose.
CI  - (c) 2010 Elsevier Inc. All rights reserved.
FAU - Kapprell, Hans-Peter
AU  - Kapprell HP
AD  - Abbott GmbH and Co. KG, 65205 Wiesbaden-Delkenheim, Germany. 
      hans-peter.kapprell@abbott.com
FAU - Stieler, Myriam
AU  - Stieler M
FAU - Oer, Michael
AU  - Oer M
FAU - Goller, Andreas
AU  - Goller A
FAU - Hausmann, Michael
AU  - Hausmann M
FAU - Schochetman, Gerald
AU  - Schochetman G
FAU - Devare, Sushil G
AU  - Devare SG
FAU - Qiu, X
AU  - Qiu X
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20100312
PL  - United States
TA  - Diagn Microbiol Infect Dis
JT  - Diagnostic microbiology and infectious disease
JID - 8305899
SB  - IM
MH  - Automation/methods
MH  - Blood/*virology
MH  - HTLV-I Infections/*diagnosis/virology
MH  - HTLV-II Infections/*diagnosis/virology
MH  - Human T-lymphotropic virus 1/*isolation & purification
MH  - Human T-lymphotropic virus 2/*isolation & purification
MH  - Humans
MH  - Mass Screening/*methods
MH  - Plasma/virology
MH  - Sensitivity and Specificity
MH  - Serum/virology
MH  - Virology/*methods
EDAT- 2010/03/17 06:00
MHDA- 2010/06/22 06:00
CRDT- 2010/03/16 06:00
PHST- 2009/10/30 00:00 [received]
PHST- 2009/12/14 00:00 [revised]
PHST- 2009/12/22 00:00 [accepted]
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - S0732-8893(09)00512-4 [pii]
AID - 10.1016/j.diagmicrobio.2009.12.021 [doi]
PST - ppublish
SO  - Diagn Microbiol Infect Dis. 2010 May;67(1):61-9. doi: 
      10.1016/j.diagmicrobio.2009.12.021. Epub 2010 Mar 12.