PMID- 20228601
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20190606
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 49
IP  - 6
DP  - 2010
TI  - Familial Hodgkin's lymphoma from the perspective of HLA.
PG  - 607-10
AB  - Although the incidence of Hodgkin lymphoma (HL)--a lymphoid tissue 
      malignity--increases in the presence of several viruses, particularly EBV, as 
      well as with autoimmune diseases and following transplantation, although to date, 
      the exact etiopathogenesis is not known. The higher frequency of HL among family 
      members suggests involvement of genetic factors in its etiology. Studies aiming 
      to elucidate the etiopathogenesis of patients with familial HL (FHL) have 
      reported that human leukocyte antigen (HLA) haplotypes might be involved. In this 
      case presentation, the associations between HLs diagnosed in a father of 
      consanguineous marriage and his two children and HLAs in other family members 
      were investigated and the findings are discussed in view of the published 
      literature; no direct association was found between HLA alleles and the 
      development of the disease in the present case with familial HL.
FAU - Sonmez, Mehmet
AU  - Sonmez M
AD  - Department of Haematology, Karadeniz Technical University, School of Medicine, 
      Trabzon, Turkey. mesonmez@yahoo.com
FAU - Erkut, Nergiz
AU  - Erkut N
FAU - Ucar, Fahri
AU  - Ucar F
FAU - Buruk, Kurtulus
AU  - Buruk K
FAU - Cobanoglu, Umit
AU  - Cobanoglu U
FAU - Bahce, Muhterem
AU  - Bahce M
FAU - Ural, Ali Ugur
AU  - Ural AU
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20100315
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Consanguinity
MH  - Female
MH  - HLA Antigens/*genetics
MH  - Haplotypes/genetics
MH  - Hodgkin Disease/*genetics/*immunology
MH  - Humans
MH  - Male
MH  - Pedigree
MH  - Young Adult
RF  - 15
EDAT- 2010/03/17 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - JST.JSTAGE/internalmedicine/49.2873 [pii]
AID - 10.2169/internalmedicine.49.2873 [doi]
PST - ppublish
SO  - Intern Med. 2010;49(6):607-10. doi: 10.2169/internalmedicine.49.2873. Epub 2010 
      Mar 15.