PMID- 20228849
OWN - NLM
STAT- MEDLINE
DCOM- 20110505
LR  - 20211203
IS  - 1476-5365 (Electronic)
IS  - 0268-3369 (Linking)
VI  - 46
IP  - 1
DP  - 2011 Jan
TI  - Observational prospective study of viral infections in children undergoing 
      allogeneic hematopoietic cell transplantation: a 3-year GETMON experience.
PG  - 119-24
LID - 10.1038/bmt.2010.52 [doi]
AB  - We studied surveillance, incidence and outcome of viral infections in children 
      undergoing allogeneic hematopoietic cell transplantation (HCT) in the main 
      pediatric transplant units in Spain. We prospectively collected data from first 
      year post-HCT in every consecutive allogeneic HCT performed during 3 years (N = 
      215): first HCT = 188 and second HCT = 27; median age = 6.6 years (0.1-20.7). 
      Most patients had acute leukemia (N = 137) and 135 recipients (63%) were CMV 
      seropositive. A total of 46 patients underwent cord blood transplant, 133 
      patients underwent HCT from alternative donors (62%) and 101 patients received 
      anti-thymocyte globulin. Observational time was completed in 137 patients, 
      whereas the remaining 78 died after a median survival time of 99 days (3-352). 
      CMV was monitored in all patients; adenovirus (ADV) and human herpesvirus 6 
      (HHV-6) were monitored in 101 and 33 patients, respectively. We found 145 viral 
      infections in 103 patients: CMV (n = 42), ADV (n = 32), HHV-6 (n = 7), 
      polyomavirus (n = 20), EBV (n = 6), VZV (n=17) and others (n = 8). CMV infection 
      was significantly higher in seropositive patients (25 vs 7%) (P = 0.02). 
      Extensive chronic GVHD (cGVHD) was significantly associated with an increased 
      rate of viral infections (12 of 16 patients with cGVHD had infections vs 91 of 
      199 without GVHD) (P = 0.035). In total, 10 patients (4.6%) died of viral 
      infections (CMV = 5, ADV = 3, respiratory = 2). We found a high incidence of 
      viral infection, but mortality was low.
FAU - Verdeguer, A
AU  - Verdeguer A
AD  - Pediatric Oncology Unit, Hospital Infantil La Fe, Valencia, Spain. 
      verdeguer_amp@gva.es
FAU - de Heredia, C D
AU  - de Heredia CD
FAU - Gonzalez, M
AU  - Gonzalez M
FAU - Martinez, A M
AU  - Martinez AM
FAU - Fernandez-Navarro, J M
AU  - Fernandez-Navarro JM
FAU - Perez-Hurtado, J M
AU  - Perez-Hurtado JM
FAU - Badell, I
AU  - Badell I
FAU - Gomez, P
AU  - Gomez P
FAU - Gonzalez, M E
AU  - Gonzalez ME
FAU - Munoz, A
AU  - Munoz A
FAU - Diaz, M A
AU  - Diaz MA
CN  - GETMON: Spanish Working Party for Blood and Marrow Transplantation in Children
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20100315
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (Antilymphocyte Serum)
SB  - IM
MH  - Adolescent
MH  - Antilymphocyte Serum/therapeutic use
MH  - Bone Marrow Transplantation
MH  - Child
MH  - Child, Preschool
MH  - Cord Blood Stem Cell Transplantation
MH  - Female
MH  - Follow-Up Studies
MH  - Graft vs Host Disease/complications/epidemiology/virology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Immunosuppression Therapy/*adverse effects
MH  - Incidence
MH  - Infant
MH  - Infant, Newborn
MH  - Leukemia/complications/therapy/virology
MH  - Male
MH  - Peripheral Blood Stem Cell Transplantation
MH  - Prospective Studies
MH  - Spain/epidemiology
MH  - Survival Analysis
MH  - Transplantation, Homologous
MH  - Viral Load
MH  - Virus Diseases/complications/*epidemiology/mortality/virology
MH  - Young Adult
EDAT- 2010/03/17 06:00
MHDA- 2011/05/06 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2011/05/06 06:00 [medline]
AID - bmt201052 [pii]
AID - 10.1038/bmt.2010.52 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2011 Jan;46(1):119-24. doi: 10.1038/bmt.2010.52. Epub 
      2010 Mar 15.