PMID- 20229185
OWN - NLM
STAT- MEDLINE
DCOM- 20100910
LR  - 20181113
IS  - 1573-4838 (Electronic)
IS  - 0957-4530 (Print)
IS  - 0957-4530 (Linking)
VI  - 21
IP  - 6
DP  - 2010 Jun
TI  - The stability mechanisms of an injectable calcium phosphate ceramic suspension.
PG  - 1799-809
LID - 10.1007/s10856-010-4047-z [doi]
AB  - Calcium phosphate ceramics are widely used as bone substitutes in dentistry and 
      orthopedic applications. For minimally invasive surgery an injectable calcium 
      phosphate ceramic suspension (ICPCS) was developed. It consists in a biopolymer 
      (hydroxypropylmethylcellulose: HPMC) as matrix and bioactive calcium phosphate 
      ceramics (biphasic calcium phosphate: BCP) as fillers. The stability of the 
      suspension is essential to this generation of "ready to use" injectable 
      biomaterial. But, during storage, the particles settle down. The engineering 
      sciences have long been interested in models describing the settling (or 
      sedimentation) of particles in viscous fluids. Our work is dedicated to the 
      comprehension of the effect of the formulation on the stability of calcium 
      phosphate suspension before and after steam sterilization. The rheological 
      characterization revealed the macromolecular behavior of the suspending medium. 
      The investigations of settling kinetics showed the influence of the BCP particle 
      size and the HPMC concentration on the settling velocity and sediment compactness 
      before and after sterilization. To decrease the sedimentation process, the 
      granule size has to be smaller and the polymer concentration has to increase. A 
      much lower sedimentation velocity, as compared to Stokes law, is observed and 
      interpreted in terms of interactions between the polymer network in solution and 
      the particles. This experimentation highlights the granules spacer property of 
      hydrophilic macromolecules that is a key issue for interconnection control, one 
      of the better ways to improve osteoconduction and bioactivity.
FAU - Fatimi, Ahmed
AU  - Fatimi A
AD  - Laboratoire d'Ingenierie Osteo-Articulaire et Dentaire (LIOAD), INSERM U791, 1 
      Place Alexis Ricordeau, BP 84215, 44042 Nantes Cedex 1, France.
FAU - Tassin, Jean-Francois
AU  - Tassin JF
FAU - Axelos, Monique A V
AU  - Axelos MA
FAU - Weiss, Pierre
AU  - Weiss P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100313
PL  - United States
TA  - J Mater Sci Mater Med
JT  - Journal of materials science. Materials in medicine
JID - 9013087
RN  - 0 (Biocompatible Materials)
RN  - 0 (Bone Substitutes)
RN  - 0 (Calcium Phosphates)
RN  - 0 (Polymers)
RN  - 3NXW29V3WO (Hypromellose Derivatives)
RN  - 9004-67-5 (Methylcellulose)
RN  - 97Z1WI3NDX (calcium phosphate)
SB  - IM
MH  - Biocompatible Materials/pharmacology
MH  - Bone Substitutes/pharmacology
MH  - Calcium Phosphates/*pharmacology
MH  - Ceramics/pharmacology
MH  - Hypromellose Derivatives
MH  - Injections
MH  - Methylcellulose/analogs & derivatives
MH  - Particle Size
MH  - Polymers/pharmacology
MH  - Rheology
MH  - Viscosity
PMC - PMC3118935
MID - HALMS507125
OID - NLM: HALMS507125
EDAT- 2010/03/17 06:00
MHDA- 2010/09/11 06:00
PMCR- 2011/06/21
CRDT- 2010/03/16 06:00
PHST- 2009/11/18 00:00 [received]
PHST- 2010/03/01 00:00 [accepted]
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/09/11 06:00 [medline]
PHST- 2011/06/21 00:00 [pmc-release]
AID - 10.1007/s10856-010-4047-z [doi]
PST - ppublish
SO  - J Mater Sci Mater Med. 2010 Jun;21(6):1799-809. doi: 10.1007/s10856-010-4047-z. 
      Epub 2010 Mar 13.