PMID- 20229477
OWN - NLM
STAT- MEDLINE
DCOM- 20100623
LR  - 20131121
IS  - 1942-7522 (Electronic)
IS  - 0145-5613 (Linking)
VI  - 89
IP  - 3
DP  - 2010 Mar
TI  - HLA-B27-associated bilateral Meniere disease.
PG  - 122-7
AB  - We describe 2 cases of bilateral Meniere disease with features resembling 
      autoimmune inner ear disease in patients who were found to be carriers of human 
      leukocyte antigen (HLA) B27. For immunohistochemical analysis, mouse inner ear 
      sections were used as the tissue substrate for reaction with serum. Both patients 
      demonstrated an increased immunofluorescence reaction compared with a normal 
      control. We suggest that an antibody-mediated mechanism may be responsible for 
      HLA-B27-associated Meniere disease.
FAU - Rawal, Shamila G
AU  - Rawal SG
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Illinois at 
      Chicago, Chicago, IL, USA.
FAU - Thakkar, Kunal H
AU  - Thakkar KH
FAU - Ziai, Kasra
AU  - Ziai K
FAU - Santi, Peter A
AU  - Santi PA
FAU - Djalilian, Hamid R
AU  - Djalilian HR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Ear Nose Throat J
JT  - Ear, nose, & throat journal
JID - 7701817
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (HLA-B27 Antigen)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Administration, Topical
MH  - Aged
MH  - Alleles
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Dexamethasone/*therapeutic use
MH  - Genotype
MH  - HLA-B27 Antigen/*genetics
MH  - Hearing Loss, Bilateral/diagnosis/etiology
MH  - Humans
MH  - Male
MH  - Meniere Disease/complications/*drug therapy/*genetics
MH  - Middle Aged
MH  - Prednisone/*therapeutic use
MH  - Severity of Illness Index
MH  - Vertigo/diagnosis/etiology
EDAT- 2010/03/17 06:00
MHDA- 2010/06/24 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/06/24 06:00 [medline]
PST - ppublish
SO  - Ear Nose Throat J. 2010 Mar;89(3):122-7.