PMID- 20229799
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 68
IP  - 3
DP  - 2010 Mar
TI  - [Management of immune reconstitution inflammatory syndrome].
PG  - 508-11
AB  - While antiretroviral therapy(ART) in HIV-infected patients results in dramatic 
      reductions in HIV viral load and subsequent improvements in CD4 cell count, part 
      of patients experience clinical deterioration as a direct consequence of rapid 
      and dysregulated restoration of antigen-specific immune responses. This is termed 
      "immune reconstitution inflammatory syndrome (IRIS)." Because there is no single 
      agreed upon definition for IRIS, the diagnosis of IRIS is clinical. Several 
      studies have demonstrated that lower CD4 cell count and higher viral load at the 
      initiation of ART increase the risk of developing IRIS. Management of IRIS 
      consists of appropriate treatment for the diseases of IRIS, control of the 
      excessive inflammation (NSAIDs or corticosteroids), and interrupting ART.
FAU - Konishi, Mitsuru
AU  - Konishi M
AD  - Center for Infectious Diseases, Nara Medical University.
FAU - Uno, Kenji
AU  - Uno K
FAU - Yoshimoto, Eiichiro
AU  - Yoshimoto E
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
SB  - IM
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/diagnosis/*therapy
RF  - 8
EDAT- 2010/03/17 06:00
MHDA- 2010/04/23 06:00
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
PST - ppublish
SO  - Nihon Rinsho. 2010 Mar;68(3):508-11.