PMID- 20230522
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20111117
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 76
IP  - 2
DP  - 2010 Aug
TI  - Major histocompatibility complex class II transactivator gene polymorphism: 
      associations with Lofgren's syndrome.
PG  - 96-101
LID - 10.1111/j.1399-0039.2010.01476.x [doi]
AB  - The major histocompatibility complex (MHC) class II transactivator (MHC2TA) is 
      known as a master regulator for expression of MHC class II molecules. In the 
      present study, we investigated the influence on the risk for sarcoidosis of two 
      variants of the MHC2TA gene, selected from previous association studies of 
      inflammatory diseases. Seven hundred and twenty-eight sarcoidosis patients and 
      873 controls matched by ethnicity were included in the study. Patients were 
      classified as with Lofgren's syndrome (or not) as subphenotypes. Individuals were 
      genotyped for two single nucleotide polymorphisms (SNPs) of the MHC2TA gene, 
      rs3087456 A/G and rs11074932 C/T, and were human leukocyte antigen 
      (HLA)-DRB1-typed. After correction for multiple testing, our data showed a 
      significant association with Lofgren's syndrome in allelic model for the 
      rs3087456 SNP, which was not detected in non-Lofgren's patients. A similar trend 
      was noted for the rs11074932 SNP. These risk factors were independent of 
      HLA-DRB1*03, which is known to be associated with Lofgren's syndrome. The finding 
      of a new genetic association between Lofgren's syndrome and MHC2TA gene 
      polymorphisms, which seems independent of HLA-DRB1*03 and relates to the 
      expression of MHC class II molecules, strongly supports the idea that Lofgren's 
      syndrome is a separate disease entity.
FAU - Grunewald, J
AU  - Grunewald J
AD  - Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet 
      and Karolinska University Hospital, Stockholm, Sweden. johan.grunewald@ki.se
FAU - Idali, F
AU  - Idali F
FAU - Kockum, I
AU  - Kockum I
FAU - Seddighzadeh, M
AU  - Seddighzadeh M
FAU - Nisell, M
AU  - Nisell M
FAU - Eklund, A
AU  - Eklund A
FAU - Padyukov, L
AU  - Padyukov L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100310
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (MHC class II transactivator protein)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Trans-Activators)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - *Genes, MHC Class II
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nuclear Proteins/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Sarcoidosis/classification/*genetics/*immunology
MH  - Syndrome
MH  - Trans-Activators/*genetics
MH  - Young Adult
EDAT- 2010/03/17 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - TAN1476 [pii]
AID - 10.1111/j.1399-0039.2010.01476.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Aug;76(2):96-101. doi: 10.1111/j.1399-0039.2010.01476.x. 
      Epub 2010 Mar 10.