PMID- 20230888
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20191210
IS  - 1879-3177 (Electronic)
IS  - 0887-2333 (Linking)
VI  - 24
IP  - 4
DP  - 2010 Jun
TI  - Toxicity of ecstasy (MDMA) towards embryonic stem cell-derived cardiac and neural 
      cells.
PG  - 1133-8
LID - 10.1016/j.tiv.2010.03.005 [doi]
AB  - "Ecstasy" or methylenedioxymethamphetamine (MDMA) is primarily a recreational 
      drug commonly used during the child bearing period, thus, there is a major 
      concern regarding the embryonic and fetal toxicity of this drug. Here, we report 
      the cardio- and neuro-toxic effects of MDMA on beating embryoid bodies (EBs) and 
      neural cell-containing EBs derived from mouse embryonic stem cell (ESCs). Based 
      on our linear discriminate function, MDMA is considered to be a moderate or weak 
      teratogen. Moreover, the generation of EBs with neural cell morphology and the 
      expression of MAP2, a mature neuron marker, decrease more when MDMA is 
      administered during the EB formation stage rather than post-plated EBs. In 
      addition, the ID50 (inhibition of differentiation) of EBs with neural cell 
      morphology is less than cardiac cells. In conclusion, MDMA causes a marked 
      reduction in beating cardiomyocytes and neurons in ESC cultures, and this drug 
      has a more potent toxicity on neural rather than cardiac cell differentiation.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Meamar, Rokhsareh
AU  - Meamar R
AD  - Department of Cell and Molecular Biology, Royan Institute for Animal 
      Biotechnology, P.O. Box 815896-8433, Esfahan, Iran.
FAU - Karamali, Fereshteh
AU  - Karamali F
FAU - Sadeghi, Hamid Mirmohamad
AU  - Sadeghi HM
FAU - Etebari, Mahmood
AU  - Etebari M
FAU - Nasr-Esfahani, Mohammad Hossein
AU  - Nasr-Esfahani MH
FAU - Baharvand, Hossein
AU  - Baharvand H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100315
PL  - England
TA  - Toxicol In Vitro
JT  - Toxicology in vitro : an international journal published in association with 
      BIBRA
JID - 8712158
RN  - 0 (Cardiotoxins)
RN  - 0 (Hallucinogens)
RN  - 0 (Illicit Drugs)
RN  - 0 (Neurotoxins)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Cardiotoxins/toxicity
MH  - Cell Differentiation/drug effects
MH  - Cell Line
MH  - Embryonic Stem Cells/*drug effects
MH  - Fetus/drug effects
MH  - Hallucinogens/*toxicity
MH  - Illicit Drugs/toxicity
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Myocytes, Cardiac/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neurons/*drug effects
MH  - Neurotoxins/toxicity
MH  - Toxicity Tests
EDAT- 2010/03/17 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/03/17 06:00
PHST- 2009/08/30 00:00 [received]
PHST- 2009/11/22 00:00 [revised]
PHST- 2010/03/10 00:00 [accepted]
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - S0887-2333(10)00069-X [pii]
AID - 10.1016/j.tiv.2010.03.005 [doi]
PST - ppublish
SO  - Toxicol In Vitro. 2010 Jun;24(4):1133-8. doi: 10.1016/j.tiv.2010.03.005. Epub 
      2010 Mar 15.