PMID- 20230920
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20120302
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 11
IP  - 5
DP  - 2012 Mar
TI  - X chromosome monosomy in primary and overlapping autoimmune diseases.
PG  - 301-4
LID - 10.1016/j.autrev.2010.03.001 [doi]
AB  - Female predominance is a common characteristic for autoimmune diseases attributed 
      to the combined effect of hormonal influence and genetic factors. Since X 
      chromosome has immunologically important genes, the age related X chromosome loss 
      could contribute to the development of autoimmunity. X chromosome monosomy (XCM) 
      has been associated with primary biliary cirrhosis (PBC) and systemic sclerosis. 
      Herein, using fluorescence in situ hybridization (FISH) with specific centromeric 
      probes, we report the rate of XCM in interphase nuclei in women with Reynolds 
      syndrome (RS), an overlapping condition of PBC and systemic sclerosis (SSc). 
      Frequency of nuclei with XCM was 12.1% (CI 95%, 8.5-17.1) in RS, 10% (7.1-13.9) 
      in PBC, 9.2% (6.0-13.9) in SSc and 6.4% (5.1-8) in age-matched healthy controls. 
      We found a significantly higher XCM frequency in RS PBC and SSc groups of 
      patients when compared with controls, p<0.01, p<0.05 and p<0.05 respectively. XCM 
      was highest in the RS group but not statistically different from PBC and SSc 
      patients. Fetal-maternal microchimerism prevalence evaluated by Q-PCR for SRY 
      sequences varies among groups, although no statistical differences were observed. 
      Besides the above, we found an apparently important additive effect (89.1%) of 
      PBC and SSc on the prevalence of XCM cells in RS patients. Another interesting 
      finding was that the prevalence of XCM cells seems not to be dependent on the 
      time of evolution of the AID studied. Moreover, the shorter time of evolution and 
      the higher prevalence of XCM interphase nuclei observed in RS patients sustain 
      our hypothesis of the additive effect abovementioned.
CI  - Copyright A(c) 2010 Elsevier B.V. All rights reserved.
FAU - Svyryd, Yevgeniya
AU  - Svyryd Y
AD  - Department of Genetics, Instituto Nacional de Ciencias Medicas y Nutricion 
      "Salvador Zubiran", Mexico.
FAU - Hernandez-Molina, Gabriela
AU  - Hernandez-Molina G
FAU - Vargas, Florencia
AU  - Vargas F
FAU - Sanchez-Guerrero, Jorge
AU  - Sanchez-Guerrero J
FAU - Segovia, Donato Alarcon
AU  - Segovia DA
FAU - Mutchinick, Osvaldo M
AU  - Mutchinick OM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100315
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
SB  - IM
MH  - Aged
MH  - Autoimmune Diseases/*genetics
MH  - Chimerism
MH  - *Chromosomes, Human, X
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Monosomy
MH  - Sex Chromosome Aberrations
EDAT- 2010/03/17 06:00
MHDA- 2012/07/04 06:00
CRDT- 2010/03/17 06:00
PHST- 2010/03/01 00:00 [received]
PHST- 2010/03/09 00:00 [accepted]
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
AID - S1568-9972(10)00057-1 [pii]
AID - 10.1016/j.autrev.2010.03.001 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2012 Mar;11(5):301-4. doi: 10.1016/j.autrev.2010.03.001. Epub 2010 
      Mar 15.