PMID- 20231199
OWN - NLM
STAT- MEDLINE
DCOM- 20100622
LR  - 20131121
IS  - 1499-2752 (Electronic)
IS  - 0315-162X (Linking)
VI  - 37
IP  - 4
DP  - 2010 Apr
TI  - Association of the MCP-1 -2518 A/G polymorphism and no association of its 
      receptor CCR2 -64 V/I polymorphism with lupus nephritis.
PG  - 776-82
LID - 10.3899/jrheum.090681 [doi]
AB  - OBJECTIVE: To evaluate whether the A/G polymorphism at position -2518 in the 
      regulatory region of the monocyte chemoattractant protein-1 (MCP-1) or the V/I 
      polymorphism at position -64 of the receptor, CCR2, are associated with lupus 
      nephritis (LN) or any clinical characteristics of the disease or with renal 
      survival in a patient population. METHODS: We selected 197 patients with lupus 
      nephritis and 220 matched healthy controls for study. MCP-1 and CCR2 genotyping 
      was performed by polymerase chain reaction. Clinical and laboratory data were 
      compiled from patients' charts over followup that ranged from 6 months to 10 
      years. RESULTS: The G/G genotype of MCP-1 was more common in LN patients (p = 
      0.019), while the A allele was associated with healthy controls (p = 0.007) as 
      was the V allele of CCR2 (p = 0.046) compared to LN patients. Clinical index 
      measures [SLE Disease Activity Index (SLEDAI)], immunological markers, renal 
      histology, renal function at enrollment, and renal survival were not influenced 
      by these polymorphisms. A less aggressive renal disease, measured by renal SLEDAI 
      index, was associated with the V allele of the CCR2 gene polymorphism. 
      CONCLUSION: These findings support that MCP-1 -2518 G/G is associated with LN but 
      there was no association of this genotype with renal function or renal survival. 
      When studying CCR2 -64 V/I polymorphism we showed a positive association of the V 
      allele with healthy controls but no association of the genotype with LN patients.
FAU - Malafronte, Patricia
AU  - Malafronte P
AD  - Nephrology Division, Department of Internal Medicine, Sao Paulo, SP, Brazil. 
      patry@terra.com.br
FAU - Vieira, Jose Mauro Jr
AU  - Vieira JM Jr
FAU - Pereira, Alexandre Carlos
AU  - Pereira AC
FAU - Krieger, Jose Eduardo
AU  - Krieger JE
FAU - Barros, Rui Toledo
AU  - Barros RT
FAU - Woronik, Viktoria
AU  - Woronik V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100315
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Analysis of Variance
MH  - Chemokine CCL2/*genetics
MH  - Creatinine/blood
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Kidney/physiopathology
MH  - Kidney Function Tests
MH  - Lupus Nephritis/blood/*genetics/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Patient Selection
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Receptors, CCR2/*genetics
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
EDAT- 2010/03/17 06:00
MHDA- 2010/06/23 06:00
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/06/23 06:00 [medline]
AID - jrheum.090681 [pii]
AID - 10.3899/jrheum.090681 [doi]
PST - ppublish
SO  - J Rheumatol. 2010 Apr;37(4):776-82. doi: 10.3899/jrheum.090681. Epub 2010 Mar 15.