PMID- 20231464
OWN - NLM
STAT- MEDLINE
DCOM- 20100428
LR  - 20240419
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 107
IP  - 13
DP  - 2010 Mar 30
TI  - Dendritic cells control T cell tonic signaling required for responsiveness to 
      foreign antigen.
PG  - 5931-6
LID - 10.1073/pnas.0911877107 [doi]
AB  - Dendritic cells (DCs) are key components of the adaptive immune system 
      contributing to initiation and regulation of T cell responses. T cells 
      continuously scan DCs in lymphoid organs for the presence of foreign antigen. 
      However, little is known about the functional consequences of these frequent T 
      cell-DC interactions without cognate antigen. Here we demonstrate that these 
      contacts in the absence of foreign antigen serve an important function, namely, 
      induction of a basal activation level in T cells required for responsiveness to 
      subsequent encounters with foreign antigens. This basal activation is provided by 
      self-recognition of MHC molecules on DCs. Following DC depletion in mice, T cells 
      became impaired in TCR signaling and immune synapse formation, and consequently 
      were hyporesponsive to antigen. This process was reversible, as T cells quickly 
      recovered when the number of DCs returned to a normal level. The extent of T cell 
      reactivity correlated with the degree of DC depletion in lymphoid organs, 
      suggesting that a full DC compartment guarantees optimal T cell responsiveness. 
      These findings indicate that DCs are specialized cells that not only present 
      foreign antigen, but also promote a "tonic" state in T cells for antigen 
      responsiveness.
FAU - Hochweller, Kristin
AU  - Hochweller K
AD  - Division of Molecular Immunology, German Cancer Research Center, 69120 
      Heidelberg, Germany.
FAU - Wabnitz, Guido H
AU  - Wabnitz GH
FAU - Samstag, Yvonne
AU  - Samstag Y
FAU - Suffner, Janine
AU  - Suffner J
FAU - Hammerling, Gunter J
AU  - Hammerling GJ
FAU - Garbi, Natalio
AU  - Garbi N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100315
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (HBEGF protein, human)
RN  - 0 (Hbegf protein, mouse)
RN  - 0 (Heparin-binding EGF-like Growth Factor)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - CD4-Positive T-Lymphocytes/cytology/immunology
MH  - CD8-Positive T-Lymphocytes/cytology/immunology
MH  - Cell Count
MH  - Cell Survival/immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Heparin-binding EGF-like Growth Factor
MH  - Humans
MH  - Immunological Synapses/immunology
MH  - Intercellular Signaling Peptides and Proteins/genetics/immunology
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Congenic
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Receptors, Antigen, T-Cell/metabolism
MH  - Recombinant Proteins/genetics/immunology
MH  - Signal Transduction/immunology
MH  - T-Lymphocytes/cytology/*immunology
MH  - Transplantation Chimera/immunology
PMC - PMC2851879
COIS- The authors declare no conflict of interest.
EDAT- 2010/03/17 06:00
MHDA- 2010/04/29 06:00
PMCR- 2010/09/30
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/29 06:00 [medline]
PHST- 2010/09/30 00:00 [pmc-release]
AID - 0911877107 [pii]
AID - 200911877 [pii]
AID - 10.1073/pnas.0911877107 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5931-6. doi: 
      10.1073/pnas.0911877107. Epub 2010 Mar 15.