PMID- 20232134
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20191008
IS  - 1573-7225 (Electronic)
IS  - 0957-5243 (Print)
IS  - 0957-5243 (Linking)
VI  - 21
IP  - 7
DP  - 2010 Jul
TI  - A case-control study of tobacco use and other non-occupational risk factors for 
      lymphoma subtypes defined by t(14; 18) translocations and bcl-2 expression.
PG  - 1147-54
LID - 10.1007/s10552-010-9531-8 [doi]
AB  - OBJECTIVE: We re-evaluated reported associations between tobacco use and other 
      factors and non-Hodgkin lymphoma (NHL) t(14; 18)-subtypes based on fluorescence 
      in situ hybridization (FISH) assays believed to be more sensitive than polymerase 
      chain reaction (PCR), previously used for detecting t(14; 18). METHODS: 
      Commercial FISH assays and bcl-2 immunostaining were performed on paraffin 
      sections to determine t(14; 18) and bcl-2 case-subtypes. Polytomous logistic 
      regression models estimated associations between NHL case-subtypes (versus 1,245 
      population-based controls) and tobacco use as well as other factors. RESULTS: 
      Adjusting for age, state, and proxy status, t(14; 18)-negative NHL was associated 
      with any tobacco use (vs. no tobacco use, OR = 1.9, 95% CI = 1.0-3.5), including 
      current smoking (vs. no cigarette use, OR = 1.9, 95% CI = 1.1-3.2). Tobacco 
      exposures were not clearly associated with t(14; 18)-positive NHL or bcl-2 
      case-subtypes. Hair-dye use and family history of a hemolymphatic cancer were 
      associated with t(14; 18)-negative NHL, but the number of exposed cases was 
      small. CONCLUSIONS: The association between t(14; 18)-negative NHL and cigarette 
      smoking was unexpected given previous evidence of associations between smoking 
      and follicular lymphoma (which is largely t(14; 18)-positive). Future studies 
      characterizing additional molecular characteristics of t(14; 18)-negative NHL may 
      help determine whether the association with smoking may have been causal versus 
      an artifact of chance or bias.
FAU - Chang, Cindy M
AU  - Chang CM
AD  - Infections and Immunoepidemiology Branch, National Cancer Institute, Rockville, 
      MD, USA. changcm@mail.nih.gov
FAU - Schroeder, Jane C
AU  - Schroeder JC
FAU - Olshan, Andrew F
AU  - Olshan AF
FAU - Dunphy, Cherie H
AU  - Dunphy CH
FAU - Huang, Wen-Yi
AU  - Huang WY
FAU - Baric, Ralph S
AU  - Baric RS
FAU - Conway, Kathleen
AU  - Conway K
FAU - Cerhan, James R
AU  - Cerhan JR
FAU - Lynch, Charles F
AU  - Lynch CF
FAU - Rothman, Nathaniel
AU  - Rothman N
FAU - Cantor, Kenneth P
AU  - Cantor KP
FAU - Blair, Aaron
AU  - Blair A
LA  - eng
GR  - P30 ES010126/ES/NIEHS NIH HHS/United States
GR  - R24 HD050924/HD/NICHD NIH HHS/United States
GR  - R03 CA71617-01/CA/NCI NIH HHS/United States
GR  - Z01 CP010119-12/Intramural NIH HHS/United States
GR  - P30ES10126/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100316
PL  - Netherlands
TA  - Cancer Causes Control
JT  - Cancer causes & control : CCC
JID - 9100846
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 14
MH  - Chromosomes, Human, Pair 18
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Incidence
MH  - Iowa/epidemiology
MH  - Logistic Models
MH  - Lymphoma, Non-Hodgkin/*epidemiology/genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - Minnesota/epidemiology
MH  - Proto-Oncogene Proteins c-bcl-2/*analysis
MH  - Risk Factors
MH  - *Smoking
MH  - Translocation, Genetic/*genetics
PMC - PMC3052629
MID - NIHMS272424
EDAT- 2010/03/17 06:00
MHDA- 2010/09/16 06:00
PMCR- 2011/07/01
CRDT- 2010/03/17 06:00
PHST- 2009/10/07 00:00 [received]
PHST- 2010/02/25 00:00 [accepted]
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - 10.1007/s10552-010-9531-8 [doi]
PST - ppublish
SO  - Cancer Causes Control. 2010 Jul;21(7):1147-54. doi: 10.1007/s10552-010-9531-8. 
      Epub 2010 Mar 16.