PMID- 2023217
OWN - NLM
STAT- MEDLINE
DCOM- 19910605
LR  - 20071114
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 18
IP  - 2
DP  - 1991 Feb
TI  - The relationship between soluble interleukin 2 receptor levels and antidouble 
      stranded DNA antibody levels in patients with systemic lupus erythematosus.
PG  - 235-40
AB  - Levels of soluble interleukin 2 receptors (IL-2R) have been found to be elevated 
      in the serum of patients with systemic lupus erythematosus (SLE) and are 
      considered an indication of immune system activation in this disease. To assess 
      the relationship between soluble IL-2R levels and other serological markers, we 
      compared levels of soluble IL-2R and anti-double stranded DNA (anti-dsDNA) 
      antibodies in SLE sera. In a cross sectional study of 34 patients with SLE, 
      soluble IL-2R levels were elevated compared with healthy individuals (1126 U/ml 
      vs 235 U/ml, p less than 0.0001), and a significant correlation between levels of 
      soluble IL-2R and anti-dsDNA antibodies was present (r = 0.543, p = 0.0009). In a 
      longitudinal study of 10 additional patients, the time courses of soluble IL-2R 
      levels and anti-dsDNA antibody measurements were similar in 3 patients. In 7 
      patients, substantial differences in the levels of soluble IL-2R and anti-dsDNA 
      antibodies over time were observed, including marked changes in anti-dsDNA 
      antibody levels that were accompanied by only minor changes in soluble IL-2R 
      levels, and soluble IL-2R measurements that were persistently elevated despite 
      generally low anti-dsDNA antibody levels. Our results indicate that soluble IL-2R 
      levels may not always parallel other serological markers of SLE, suggesting 
      measurement of different facets of immune system activation by various assays.
FAU - Ward, M M
AU  - Ward MM
AD  - Department of Medicine, Duke University, Durham, NC.
FAU - Dooley, M A
AU  - Dooley MA
FAU - Christenson, V D
AU  - Christenson VD
FAU - Pisetsky, D S
AU  - Pisetsky DS
LA  - eng
GR  - 5-P01-AI-23308/AI/NIAID NIH HHS/United States
GR  - 5P50-AR-39162/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Receptors, Interleukin-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Antinuclear/*analysis/immunology
MH  - Cross-Sectional Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Immune System/immunology/ultrastructure
MH  - Longitudinal Studies
MH  - Lupus Erythematosus, Systemic/blood/*immunology
MH  - Male
MH  - Middle Aged
MH  - Receptors, Interleukin-2/*blood
EDAT- 1991/02/01 00:00
MHDA- 1991/02/01 00:01
CRDT- 1991/02/01 00:00
PHST- 1991/02/01 00:00 [pubmed]
PHST- 1991/02/01 00:01 [medline]
PHST- 1991/02/01 00:00 [entrez]
PST - ppublish
SO  - J Rheumatol. 1991 Feb;18(2):235-40.