PMID- 20235216
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20200225
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 33
IP  - 3
DP  - 2010 Mar
TI  - QRS duration is associated with atrial fibrillation in patients with left 
      ventricular dysfunction.
PG  - 132-8
LID - 10.1002/clc.20714 [doi]
AB  - BACKGROUND: QRSduration (QRSd) is associated with higher mortality and morbidity 
      in patients with left ventricular (LV) dysfunction. The association between QRSd 
      and atrial fibrillation (AF) has not been studied in this patient population. 
      OBJECTIVES: To investigate the association between QRSd and AF in patients with 
      LV dysfunction. METHODS: Data were obtained from the National Registry to Advance 
      Heart Health (ADVANCENT) registry, a prospective multicenter registry of patients 
      with left ventricular ejection fraction (LVEF) < or = 40%. A total of 25 268 
      patients from 106 centers in the United States, were enrolled between June 2003 
      and November 2004. Demographic and clinical characteristics of patients were 
      collected from interviews and medical records. RESULTS: : Mean age was 66.3+/-13 
      years, 71.5% were males, and 81.9% were white. A total of 14 452 (57.8%) patients 
      had a QRSd < 120 ms, 5304 (21.2%) had a QRSd between 120 and 150 ms, and 5269 
      (21%) had a QRSd > 150 ms. Atrial fibrillation occurred in 20.9%, 27.5%, and 
      35.5% of patients in the QRS groups, respectively (P < 0.0001). After adjusting 
      for potential AF risk factors (age, gender, race, body mass index, hypertension, 
      diabetes, renal failure, cancer, lung disease, New York Heart Association [NYHA] 
      class, ejection fraction, etiology of cardiomyopathy) and the use of 
      angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, 
      beta-blockers, and lipid lowering drugs, QRS duration remained independently 
      associated with AF (odds ratio: 1.20, 95% confidence interval: 1.14-1.25). 
      CONCLUSION: In this large cohort of patients, QRSd was strongly associated with 
      AF and therefore may predict the occurrence of this arrhythmia in patients with 
      LV dysfunction. This association persisted after adjusting for disease severity, 
      comorbid conditions, and the use of medications known to be protective against 
      AF.
CI  - Copyright (c) 2010 Wiley Periodicals, Inc.
FAU - El-Chami, Mikhael F
AU  - El-Chami MF
AD  - Division of Cardiology, Section of Electrophysiology, Emory University School of 
      Medicine, Atlanta, Georgia.
FAU - Brancato, Candace
AU  - Brancato C
FAU - Langberg, Jonathan
AU  - Langberg J
FAU - Delurgio, David B
AU  - Delurgio DB
FAU - Bush, Heather
AU  - Bush H
FAU - Brosius, Lynne
AU  - Brosius L
FAU - Leon, Angel R
AU  - Leon AR
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
SB  - IM
CIN - Clin Cardiol. 2011 Mar;34(3):E12; author reply E13. PMID: 21280057
MH  - Aged
MH  - Analysis of Variance
MH  - Atrial Fibrillation/*epidemiology/physiopathology
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Comorbidity
MH  - Confidence Intervals
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Prevalence
MH  - Registries
MH  - Regression Analysis
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Time Factors
MH  - United States/epidemiology
MH  - Ventricular Dysfunction, Left/*epidemiology/physiopathology
MH  - Ventricular Function, Left
PMC - PMC6653136
EDAT- 2010/03/18 06:00
MHDA- 2011/06/08 06:00
PMCR- 2010/03/16
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/18 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
PHST- 2010/03/16 00:00 [pmc-release]
AID - CLC20714 [pii]
AID - 10.1002/clc.20714 [doi]
PST - ppublish
SO  - Clin Cardiol. 2010 Mar;33(3):132-8. doi: 10.1002/clc.20714.