PMID- 20236043
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20191111
IS  - 1875-6166 (Electronic)
IS  - 1871-5249 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Mar
TI  - Emerging evidence for the role of neurotransmitters in the modulation of T cell 
      responses to cognate ligands.
PG  - 65-83
AB  - Dendritic cells (DCs) are responsible of priming T cells and promoting their 
      differentiation from naive T cells into appropriate effector cells. Each 
      different phenotype of effector T cells promotes the elimination of a determined 
      kind of pathogen or tumour. Thus, DCs and T cells play critical roles on 
      orchestrating adaptive immune responses against specific threats. Because of 
      their fundamental functions at controlling immunity, DCs and T cells require 
      tight regulatory mechanisms to ensure efficient, but safe, immune responses. 
      Several studies have shown that neurotransmitters, in addition to mediate 
      interactions into the nervous system, can contribute to the modulation of 
      immunity by promoting the communication between nervous and immune systems and in 
      the interaction between different immune cells. Due to the pivotal role that the 
      DC-T cell interaction plays in the development and regulation of adaptive immune 
      responses, it is important to understand how the function of these cells may be 
      regulated by neurotransmitters. Here, we review the emerging role of 
      neurotransmitters as regulators of DC and T cell physiology and also how these 
      molecules, by acting on the DC-T cell interaction, may modulate the fate of T 
      cells and, therefore, the nature of the adaptive immune response. Moreover, we 
      discuss how alterations on the neurotransmitter-mediated immune regulatory 
      mechanisms can contribute to the onset of immune-related disorders. In addition, 
      we discuss potential new targets for the design of strategies for therapies 
      against tumours, autoimmunity and neuro-immune related diseases.
FAU - Pacheco, Rodrigo
AU  - Pacheco R
AD  - Fundacion Ciencia para la Vida, Santiago, Chile. rodrigo.pacheco@bionova.cl
FAU - Riquelme, Erick
AU  - Riquelme E
FAU - Kalergis, Alexis Mikes
AU  - Kalergis AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Cent Nerv Syst Agents Med Chem
JT  - Central nervous system agents in medicinal chemistry
JID - 101269163
RN  - 0 (Ligands)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 333DO1RDJY (Serotonin)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - N9YNS0M02X (Acetylcholine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Adaptive Immunity/physiology
MH  - Antigen Presentation
MH  - Dendritic Cells/*immunology
MH  - Dopamine/metabolism
MH  - Glutamic Acid/metabolism
MH  - Immune System Diseases/immunology/physiopathology
MH  - Immunity, Innate/physiology
MH  - Immunological Synapses/immunology
MH  - Ligands
MH  - Lymphocyte Activation/*immunology
MH  - Neurotransmitter Agents/*immunology
MH  - Receptors, Antigen, T-Cell/metabolism
MH  - Serotonin/metabolism
MH  - T-Lymphocyte Subsets/immunology
MH  - T-Lymphocytes/*immunology
RF  - 175
EDAT- 2010/03/20 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - 10.2174/187152410790780154 [doi]
PST - ppublish
SO  - Cent Nerv Syst Agents Med Chem. 2010 Mar;10(1):65-83. doi: 
      10.2174/187152410790780154.