PMID- 20236137
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20110404
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Mar-Apr
TI  - De novo membranous nephropathy and antibody-mediated rejection in transplanted 
      kidney.
PG  - 191-200
LID - 10.1111/j.1399-0012.2010.01213.x [doi]
AB  - BACKGROUND: The etiology of de novo membranous nephropathy (MN) after kidney 
      transplantation is still uncertain. Immunological response to various allograft 
      antigens is speculated to be a candidate for the etiology. METHODS: Seventeen 
      patients with post-transplant de novo MN were studied clinically and 
      pathologically in comparison with control post-transplant patients without MN. 
      Double immunofluorescent staining was performed to identify the presence of 
      donor-specific human leukocyte antigen (HLA) combined with IgG in the deposits on 
      glomerular capillary walls. RESULTS: De novo MN occurs in relatively late period 
      after transplantation (102.1 +/- 68.3 months), presenting various degree of 
      proteinuria. Histological findings associated with antibody-mediated rejection 
      (AMR), such as peritubular capillaritis and C4d deposition in peritubular 
      capillary, were more frequently observed in the patients with de novo MN than the 
      non-MN control patients. Donor-specific antibody (DSA) was detected in five 
      patients at the time of biopsy. In one case of de novo MN with DSA, a 
      donor-derived HLA was identified in the subepithelial deposits on the glomerular 
      capillary walls combined with IgG deposition. CONCLUSIONS: DSA and AMR might play 
      some roles for the pathogenesis in some patients with de novo MN after kidney 
      transplantation.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Honda, Kazuho
AU  - Honda K
AD  - Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan. 
      honda@research.twmu.ac.jp
FAU - Horita, Shigeru
AU  - Horita S
FAU - Toki, Daisuke
AU  - Toki D
FAU - Taneda, Sekiko
AU  - Taneda S
FAU - Nitta, Kosaku
AU  - Nitta K
FAU - Hattori, Motoshi
AU  - Hattori M
FAU - Tanabe, Kazunari
AU  - Tanabe K
FAU - Teraoka, Satoshi
AU  - Teraoka S
FAU - Oda, Hideaki
AU  - Oda H
FAU - Yamaguchi, Yutaka
AU  - Yamaguchi Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Glomerulonephritis, Membranous/*etiology
MH  - Graft Rejection/*etiology
MH  - Humans
MH  - Isoantibodies/*blood/*immunology
MH  - Kidney Transplantation/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2010/03/20 06:00
MHDA- 2011/08/17 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - CTR1213 [pii]
AID - 10.1111/j.1399-0012.2010.01213.x [doi]
PST - ppublish
SO  - Clin Transplant. 2011 Mar-Apr;25(2):191-200. doi: 
      10.1111/j.1399-0012.2010.01213.x.