PMID- 20236564
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20220331
IS  - 1475-2727 (Electronic)
IS  - 1368-9800 (Linking)
VI  - 13
IP  - 12
DP  - 2010 Dec
TI  - Prevalence of hyperhomocysteinaemia in a Chinese elderly population.
PG  - 1974-81
LID - 10.1017/S1368980010000546 [doi]
AB  - OBJECTIVE: To evaluate plasma homocysteine (Hcy) levels and prevalence rates of 
      hyperhomocysteinaemia (HHCY) in elderly Chinese individuals. DESIGN: A 
      cross-sectional study. SETTING: The study was conducted in 2006 in two counties 
      from the north and the south of China. SUBJECTS: A total of 810 individuals aged 
      65-74 years were recruited. Demographic characteristics and lifestyle factors 
      were assessed through questionnaire interviews and physical examination. Hcy and 
      folate levels were measured in blood samples. The distribution of Hcy level was 
      analysed according to Hcy-related factors. RESULTS: Northerners had higher Hcy 
      levels (18.42 mumol/l) than southerners (10.20 mumol/l). Plasma Hcy was higher in 
      men than in women and greater in smokers than in non-smokers. The prevalence rate 
      of HHCY was 51.6 % in the north and 10.1 % in the south (P < 0.001). Hcy and 
      plasma folate showed an inverse correlation (Spearman's r = -0.44, P < 0.001; 
      partial r = -0.229, P < 0.001). Region, gender, alcohol consumption and plasma 
      folate were associated with HHCY among these elderly populations. CONCLUSIONS: 
      The results demonstrated that plasma Hcy levels and the prevalence rates of HHCY 
      in Chinese elderly are considerably higher than those found in other countries, 
      and substantial regional variations occur within China. The predominant 
      determining factors of HHCY were region, gender, alcohol consumption and plasma 
      folate. The elevated Hcy levels among elderly Chinese populations need to be 
      decreased urgently.
FAU - Qu, Quan-Gang
AU  - Qu QG
AD  - Institute of Reproductive and Child Health, Peking University Health Science 
      Center, 38 Xueyuan Road, Haidian District, Beijing 100191, People's Republic of 
      China.
FAU - Gao, Jin-Ji
AU  - Gao JJ
FAU - Liu, Jian-Meng
AU  - Liu JM
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100318
PL  - England
TA  - Public Health Nutr
JT  - Public health nutrition
JID - 9808463
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Aged
MH  - Alcohol Drinking/epidemiology
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Folic Acid/blood
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*blood/*epidemiology
MH  - Life Style
MH  - Male
MH  - Prevalence
MH  - Sex Factors
MH  - Surveys and Questionnaires
MH  - Vitamin B 12/blood
EDAT- 2010/03/20 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - S1368980010000546 [pii]
AID - 10.1017/S1368980010000546 [doi]
PST - ppublish
SO  - Public Health Nutr. 2010 Dec;13(12):1974-81. doi: 10.1017/S1368980010000546. Epub 
      2010 Mar 18.