PMID- 20237358
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20151119
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Jun
TI  - Significantly elevated concentration of plasma monocyte chemotactic protein 1 of 
      patients with pelvic inflammatory disease.
PG  - 549-55
LID - 10.1177/1933719110362593 [doi]
AB  - Our goal was to compare the expression of plasma monocyte chemotactic protein 1 
      (MCP-1) and the gene polymorphism in patients with pelvic inflammatory disease 
      (PID) and healthy controls. The enzyme-linked immunosorbent assay (ELISA) and 
      polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) 
      were, respectively, used to measure the plasma MCP-1 level and MCP-1 polymorphism 
      in 70 healthy controls and in 64 patients with PID before and after they received 
      routine treatment protocols. We found plasma MCP-1 was significantly elevated in 
      patients with PID compared to that in normal controls and decreased significantly 
      compared to that in patients with PID after they received treatment. The 
      increased expression of plasma MCP-1 was significantly correlated with the cell 
      counts of white blood cells (WBCs) in blood and the level of plasma C-reactive 
      protein (CRP) of patients with PID before they received treatment. There was no 
      association between MCP-1 -2518G/A SNP and its gene expression levels and PID 
      susceptibility. Elevated plasma MCP-1 could be a biological marker for the 
      diagnosis and to be a new strategy for target therapy of pelvic inflammatory 
      disease.
FAU - Hsiao, Pei-Ching
AU  - Hsiao PC
AD  - Department of Internal Medicine, Chung Shan Medical University Hospital, 
      Taichung, Taiwan.
FAU - Wang, Po-Hui
AU  - Wang PH
FAU - Tee, Yi-Torng
AU  - Tee YT
FAU - Yang, Shun-Fa
AU  - Yang SF
FAU - Su, Pen-Hua
AU  - Su PH
FAU - Chen, Yi-Chen
AU  - Chen YC
FAU - Lin, Long-Yau
AU  - Lin LY
FAU - Tsai, Hsiu-Ting
AU  - Tsai HT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100317
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood/genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Humans
MH  - Pelvic Inflammatory Disease/*blood/diagnosis/genetics
MH  - Polymorphism, Single Nucleotide
EDAT- 2010/03/20 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - 1933719110362593 [pii]
AID - 10.1177/1933719110362593 [doi]
PST - ppublish
SO  - Reprod Sci. 2010 Jun;17(6):549-55. doi: 10.1177/1933719110362593. Epub 2010 Mar 
      17.