PMID- 20237478
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20220321
IS  - 1471-0080 (Electronic)
IS  - 1471-0072 (Print)
IS  - 1471-0072 (Linking)
VI  - 11
IP  - 4
DP  - 2010 Apr
TI  - A nucleator arms race: cellular control of actin assembly.
PG  - 237-51
LID - 10.1038/nrm2867 [doi]
AB  - For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of 
      nucleation-promoting factors and formins were the only molecules known to 
      directly nucleate actin filament formation de novo. However, the past several 
      years have seen a surge in the discovery of mammalian proteins with roles in 
      actin nucleation and dynamics. Newly recognized nucleation-promoting factors, 
      such as WASP and SCAR homologue (WASH), WASP homologue associated with actin, 
      membranes and microtubules (WHAMM), and junction-mediating regulatory protein 
      (JMY), stimulate ARP2/3 activity at distinct cellular locations. Formin 
      nucleators with additional biochemical and cellular activities have also been 
      uncovered. Finally, the Spire, cordon-bleu and leiomodin nucleators have revealed 
      new ways of overcoming the kinetic barriers to actin polymerization.
FAU - Campellone, Kenneth G
AU  - Campellone KG
AD  - Department of Molecular and Cell Biology, University of California, Berkeley, 
      California 94720, USA. campellone@berkeley.edu
FAU - Welch, Matthew D
AU  - Welch MD
LA  - eng
GR  - R01-GM059609/GM/NIGMS NIH HHS/United States
GR  - R01-AI074760/AI/NIAID NIH HHS/United States
GR  - R01 GM059609-11/GM/NIGMS NIH HHS/United States
GR  - R01 AI074760/AI/NIAID NIH HHS/United States
GR  - R01 GM059609/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100318
PL  - England
TA  - Nat Rev Mol Cell Biol
JT  - Nature reviews. Molecular cell biology
JID - 100962782
RN  - 0 (Actin-Related Protein 2-3 Complex)
RN  - 0 (Actins)
RN  - 0 (JMY protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Wiskott-Aldrich Syndrome Protein Family)
SB  - IM
MH  - Actin Cytoskeleton/*metabolism
MH  - Actin-Related Protein 2-3 Complex/metabolism
MH  - Actins/*metabolism
MH  - Animals
MH  - Humans
MH  - Nuclear Proteins/physiology
MH  - Trans-Activators/physiology
MH  - Wiskott-Aldrich Syndrome Protein Family/physiology
PMC - PMC2929822
MID - NIHMS206071
EDAT- 2010/03/20 06:00
MHDA- 2010/04/14 06:00
PMCR- 2010/10/01
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
PHST- 2010/10/01 00:00 [pmc-release]
AID - nrm2867 [pii]
AID - 10.1038/nrm2867 [doi]
PST - ppublish
SO  - Nat Rev Mol Cell Biol. 2010 Apr;11(4):237-51. doi: 10.1038/nrm2867. Epub 2010 Mar 
      18.