PMID- 20237994
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20240322
IS  - 1936-0568 (Electronic)
IS  - 1936-055X (Print)
IS  - 1936-055X (Linking)
VI  - 4
IP  - 1
DP  - 2010 Mar
TI  - The small round blue cell tumors of the sinonasal area.
PG  - 84-93
LID - 10.1007/s12105-009-0158-6 [doi]
AB  - The diagnostic classification of small round blue cell tumors of the sinonasal 
      area to include diverse malignancies of epithelial, hematolymphoid, 
      neuroectodermal, and mesenchymal origin is challenging to the surgical 
      pathologist using conventional histopathologic approaches because the 
      cytomorphologic features are often overlapping or indistinctive. Rare or 
      occasional clinical presentations in atypical age groups or unusual locations, as 
      well as small biopsy samples may further complicate the differential diagnosis. 
      Immunohistochemistry represents an extensively investigated ancillary technique 
      that may aid in the provision of a definitive diagnosis. In recent years, certain 
      small round blue cell tumors have been shown by cytogenetic analysis to have 
      specific and primary chromosomal alterations, providing clinicians with a 
      valuable tool to enhance their diagnostic armamentarium. The addition of 
      molecular cytogenetic [fluorescence in situ hybridization (FISH), comparative 
      genomic hybridization (CGH)] and molecular pathologic [polymerase chain reaction 
      (PCR) and reverse transcriptase (RT)-PCR] approaches has further enhanced the 
      sensitivity and accuracy of detecting these genetic alterations including 
      assessment in formalin-fixed, paraffin-embedded tissues. Establishing an accurate 
      diagnosis of a small round blue cell tumor of the sinonasal tract frequently 
      requires adjunctive studies including immunohistochemical and molecular analyses.
FAU - Bridge, Julia A
AU  - Bridge JA
AD  - Department of Pathology, 983135 Nebraska Medical Center, University of Nebraska 
      Medical Center, Omaha, NE 68198-3135, USA. jbridge@unmc.edu
FAU - Bowen, Joslin M
AU  - Bowen JM
FAU - Smith, Russell B
AU  - Smith RB
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100126
PL  - United States
TA  - Head Neck Pathol
JT  - Head and neck pathology
JID - 101304010
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Biomarkers, Tumor/metabolism
MH  - Comparative Genomic Hybridization
MH  - DNA, Neoplasm/analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Paranasal Sinus Neoplasms/*diagnosis/genetics/metabolism
MH  - Pathology, Molecular/methods
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sarcoma, Small Cell/*diagnosis/genetics/metabolism
PMC - PMC2825526
EDAT- 2010/03/20 06:00
MHDA- 2010/09/03 06:00
PMCR- 2011/01/26
CRDT- 2010/03/19 06:00
PHST- 2009/12/01 00:00 [received]
PHST- 2009/12/19 00:00 [accepted]
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
PHST- 2011/01/26 00:00 [pmc-release]
AID - 158 [pii]
AID - 10.1007/s12105-009-0158-6 [doi]
PST - ppublish
SO  - Head Neck Pathol. 2010 Mar;4(1):84-93. doi: 10.1007/s12105-009-0158-6. Epub 2010 
      Jan 26.