PMID- 2029074
OWN - NLM
STAT- MEDLINE
DCOM- 19910613
LR  - 20191029
IS  - 0192-8562 (Print)
IS  - 0192-8562 (Linking)
VI  - 13
IP  - 1
DP  - 1991 Spring
TI  - Successful treatment of severe aplastic anemia by bone marrow transplantation 
      from HLA nonidentical family members: preliminary results utilizing 
      cyclophosphamide and 600 cGY fractionated total body irradiation.
PG  - 29-33
AB  - We have performed bone marrow transplants on four children with severe aplastic 
      anemia who lacked an human leukocyte antigen (HLA)-identical sibling donor. 
      Patients were prepared with cyclophosphamide and 600 cGy fractionated total body 
      irradiation, and then received marrow from a parent donor mismatched for one (two 
      patients), two (one patient), or three (one patient) HLA antigens. All four 
      patients engrafted. One died early of acute graft-versus-host disease. The three 
      others showed sustained complete hematopoietic reconstitution. Two are alive and 
      hematologically normal 43-87 months after transplant. Both have had acute and 
      chronic graft-versus-host disease (CGVHD), and one of the two remains on 
      immunosuppressive drugs. The fourth died at 48 months after transplant of CGVHD. 
      The previous experience with HLA-incompatible marrow transplants is reviewed, and 
      the rationale for this preparative regimen is discussed. Cyclophosphamide and 600 
      cGy fractionated total body irradiation is an effective preparative regimen for 
      children with severe aplastic anemia receiving transplants from HLA-nonidentical 
      parental donors, allowing engraftment and full hematologic reconstitution.
FAU - Gordon, B G
AU  - Gordon BG
AD  - Section of Pediatric Hematology/Oncology, University Nebraska Medical Center, 
      Omaha.
FAU - Strandjord, S E
AU  - Strandjord SE
FAU - Warkentin, P I
AU  - Warkentin PI
FAU - Kadushin, J
AU  - Kadushin J
FAU - Coccia, P F
AU  - Coccia PF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Pediatr Hematol Oncol
JT  - The American journal of pediatric hematology/oncology
JID - 7908071
RN  - 0 (HLA Antigens)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
CIN - Am J Pediatr Hematol Oncol. 1991 Spring;13(1):1-2. PMID: 2029071
MH  - Adolescent
MH  - Anemia, Aplastic/*therapy
MH  - Bone Marrow Transplantation/adverse effects/*immunology/methods
MH  - Child, Preschool
MH  - Cyclophosphamide/*therapeutic use
MH  - Graft vs Host Disease/etiology/prevention & control
MH  - HLA Antigens/*analysis
MH  - Humans
MH  - Severity of Illness Index
MH  - *Tissue Donors
MH  - *Whole-Body Irradiation
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1097/00043426-199121000-00007 [doi]
PST - ppublish
SO  - Am J Pediatr Hematol Oncol. 1991 Spring;13(1):29-33. doi: 
      10.1097/00043426-199121000-00007.