PMID- 20298397
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20151119
IS  - 1752-699X (Electronic)
IS  - 1752-6981 (Linking)
VI  - 3
IP  - 3
DP  - 2009 Jul
TI  - Relationship between exhaled nitric oxide and IgE sensitisation in patients with 
      asthma: influence of steroid treatment.
PG  - 143-51
LID - 10.1111/j.1752-699X.2008.00124.x [doi]
AB  - INTRODUCTION: The influence of the degree of immunoglobulin E (IgE) sensitisation 
      on the fraction of expired nitric oxide (FE(NO)) in asthma patients being treated 
      with inhaled corticosteroids (ICS) is not well known. OBJECTIVES: To investigate 
      the relationship between IgE sensitisation and FE(NO), and the effect of a 
      step-up in ICS treatment on this relationship, in patients with allergic asthma. 
      METHODS: A primary health care centre recruited 20 non-smoking patients with 
      perennial allergic asthma (18 years-50 years, six male) outside the pollen 
      season. At every visit (0, 2, 4, 8 weeks), FE(NO) was measured and an exposure 
      questionnaire was completed. ICS dose was adjusted according to FE(NO) (>or=22 
      ppb prescribed increase in ICS). Quantitative analyses of serum IgE (eight common 
      aeroallergens) confirmed allergy. RESULTS: At baseline, FE(NO) and the sum of IgE 
      antibody titres for perennial allergens correlated significantly (r = 0.47, P = 
      0.04). After a step-up in ICS treatment, this correlation had disappeared. Nine 
      patients had persistently elevated FE(NO) at last visit (mean 35 ppb vs 16 ppb). 
      This group was more frequently exposed to relevant allergens or colds (89% vs 27% 
      of patients, P < 0.05) and had higher IgE antibody titres (perennial allergens) 
      compared with the normalised group (mean 28.9 kU/L vs 10.7 kU/L, P < 0.05). 
      CONCLUSION: Serum IgE against perennial allergens and FE(NO) correlate in 
      patients with allergic asthma. However, this relationship disappears after a 
      high-dose ICS regimen, suggesting that FE(NO) relates to bronchial inflammation 
      and not IgE levels per se. High degree of IgE sensitisation together with 
      allergen exposure may lead to ICS-resistant airways inflammation.
FAU - Syk, Jorgen
AU  - Syk J
AD  - Department of Neurobiology, Caring Sciences and Society, Karolinska Institutet, 
      Stockholm, Sweden. jorgen.syk@ptj.se
FAU - Unden, Anna-Lena
AU  - Unden AL
FAU - Alving, Kjell
AU  - Alving K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Respir J
JT  - The clinical respiratory journal
JID - 101315570
RN  - 0 (Androstadienes)
RN  - 0 (Bronchodilator Agents)
RN  - 0 (Ethanolamines)
RN  - 0 (Glucocorticoids)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 51333-22-3 (Budesonide)
RN  - CUT2W21N7U (Fluticasone)
RN  - W34SHF8J2K (Formoterol Fumarate)
SB  - IM
MH  - Administration, Inhalation
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Androstadienes/administration & dosage/*therapeutic use
MH  - Asthma/*drug therapy/*immunology
MH  - Bronchodilator Agents/administration & dosage/*therapeutic use
MH  - Budesonide/administration & dosage/*therapeutic use
MH  - Ethanolamines/administration & dosage/therapeutic use
MH  - Female
MH  - Fluticasone
MH  - Formoterol Fumarate
MH  - Glucocorticoids/administration & dosage/*therapeutic use
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/*analysis/immunology
MH  - Quality of Life
MH  - Respiratory Function Tests
MH  - Surveys and Questionnaires
EDAT- 2010/03/20 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/03/20 06:00
PHST- 2010/03/20 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - CRJ124 [pii]
AID - 10.1111/j.1752-699X.2008.00124.x [doi]
PST - ppublish
SO  - Clin Respir J. 2009 Jul;3(3):143-51. doi: 10.1111/j.1752-699X.2008.00124.x.