PMID- 20298965
OWN - NLM
STAT- MEDLINE
DCOM- 20100412
LR  - 20140815
IS  - 1474-4465 (Electronic)
IS  - 1474-4422 (Linking)
VI  - 9
IP  - 4
DP  - 2010 Apr
TI  - Voltage-gated sodium channels as therapeutic targets in epilepsy and other 
      neurological disorders.
PG  - 413-24
LID - 10.1016/S1474-4422(10)70059-4 [doi]
AB  - Voltage-gated sodium channels (VGSCs) are key mediators of intrinsic neuronal and 
      muscle excitability. Abnormal VGSC activity is central to the pathophysiology of 
      epileptic seizures, and many of the most widely used antiepileptic drugs, 
      including phenytoin, carbamazepine, and lamotrigine, are inhibitors of VGSC 
      function. These antiepileptic drugs might also be efficacious in the treatment of 
      other nervous system disorders, such as migraine, multiple sclerosis, 
      neurodegenerative diseases, and neuropathic pain. In this Review, we summarise 
      the structure and function of VGSCs and their involvement in the pathophysiology 
      of several neurological disorders. We also describe the biophysical and molecular 
      bases for the mechanisms of action of antiepileptic VGSC blockers and discuss the 
      efficacy of these drugs in the treatment of epileptic and non-epileptic 
      disorders. Overall, clinical and experimental data indicate that these drugs are 
      efficacious for a range of diseases, and that the development of drugs with 
      enhanced selectivity for specific VGSC isoforms might be an effective and novel 
      approach for the treatment of several neurological diseases.
CI  - 2010 Elsevier Ltd. All rights reserved.
FAU - Mantegazza, Massimo
AU  - Mantegazza M
AD  - Dipartimento di Neurofisiopatologia, Fondazione Istituto Neurologico C Besta, 
      Milano, Italy.
FAU - Curia, Giulia
AU  - Curia G
FAU - Biagini, Giuseppe
AU  - Biagini G
FAU - Ragsdale, David S
AU  - Ragsdale DS
FAU - Avoli, Massimo
AU  - Avoli M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Lancet Neurol
JT  - The Lancet. Neurology
JID - 101139309
RN  - 0 (Sodium Channel Blockers)
RN  - 0 (Sodium Channels)
SB  - IM
MH  - Animals
MH  - Epilepsy/*drug therapy/*metabolism
MH  - Humans
MH  - Nervous System Diseases/drug therapy/metabolism
MH  - Sodium Channel Blockers/*therapeutic use
MH  - Sodium Channels/*metabolism
RF  - 113
EDAT- 2010/03/20 06:00
MHDA- 2010/04/13 06:00
CRDT- 2010/03/20 06:00
PHST- 2010/03/20 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/04/13 06:00 [medline]
AID - S1474-4422(10)70059-4 [pii]
AID - 10.1016/S1474-4422(10)70059-4 [doi]
PST - ppublish
SO  - Lancet Neurol. 2010 Apr;9(4):413-24. doi: 10.1016/S1474-4422(10)70059-4.