PMID- 20298966
OWN - NLM
STAT- MEDLINE
DCOM- 20100412
LR  - 20220410
IS  - 1474-4465 (Electronic)
IS  - 1474-4422 (Print)
IS  - 1474-4422 (Linking)
VI  - 9
IP  - 4
DP  - 2010 Apr
TI  - Progressive multifocal leukoencephalopathy and other disorders caused by JC 
      virus: clinical features and pathogenesis.
PG  - 425-37
LID - 10.1016/S1474-4422(10)70040-5 [doi]
AB  - Progressive multifocal leukoencephalopathy (PML) is a rare but often fatal brain 
      disease caused by reactivation of the polyomavirus JC. Knowledge of the 
      characteristics of PML has substantially expanded since the introduction of 
      combination antiretroviral therapy during the HIV epidemic and the development of 
      immune reconstitution inflammatory syndrome (IRIS) in patients with PML. 
      Recently, the monoclonal antibodies natalizumab, efalizumab, and rituximab--used 
      for the treatment of multiple sclerosis, psoriasis, haematological malignancies, 
      Crohn's disease, and rheumatic diseases--have been associated with PML. 
      Additionally, the JC virus can also lead to novel neurological disorders such as 
      JC virus granule cell neuronopathy and JC virus encephalopathy, and might also 
      cause meningitis. The increasingly diverse populations at risk and the recent 
      discovery of the presence of the JC virus in the grey matter invite us to 
      reappraise the pathogenesis of this virus in the CNS.
CI  - 2010 Elsevier Ltd. All rights reserved.
FAU - Tan, Chen S
AU  - Tan CS
AD  - Division of Viral Pathogenesis, Department of Neurology, Beth Israel Deaconess 
      Medical Center, Boston, MA 02215, USA.
FAU - Koralnik, Igor J
AU  - Koralnik IJ
LA  - eng
GR  - T32 AI007061/AI/NIAID NIH HHS/United States
GR  - K24 NS 060950/NS/NINDS NIH HHS/United States
GR  - P30 AI60354/AI/NIAID NIH HHS/United States
GR  - K08 NS064215-01A1/NS/NINDS NIH HHS/United States
GR  - R01 NS041198-09/NS/NINDS NIH HHS/United States
GR  - K08 NS064215/NS/NINDS NIH HHS/United States
GR  - NS 047029/NS/NINDS NIH HHS/United States
GR  - R01 NS 041198/NS/NINDS NIH HHS/United States
GR  - R01 NS047029-06/NS/NINDS NIH HHS/United States
GR  - R01 NS041198/NS/NINDS NIH HHS/United States
GR  - K08 NS 064215-01A1/NS/NINDS NIH HHS/United States
GR  - K24 NS060950-03/NS/NINDS NIH HHS/United States
GR  - P30 AI060354/AI/NIAID NIH HHS/United States
GR  - R01 NS047029/NS/NINDS NIH HHS/United States
GR  - K24 NS060950/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Lancet Neurol
JT  - The Lancet. Neurology
JID - 101139309
SB  - IM
CIN - Clin Neuroradiol. 2010 Jun;20(2):141-2. PMID: 20512302
MH  - Humans
MH  - *JC Virus
MH  - Leukoencephalopathy, Progressive 
      Multifocal/diagnosis/pathology/*physiopathology/therapy
MH  - Polyomavirus Infections/diagnosis/pathology/*physiopathology/therapy
MH  - Tumor Virus Infections/diagnosis/pathology/*physiopathology/therapy
PMC - PMC2880524
MID - NIHMS200940
EDAT- 2010/03/20 06:00
MHDA- 2010/04/13 06:00
PMCR- 2011/04/01
CRDT- 2010/03/20 06:00
PHST- 2010/03/20 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/04/13 06:00 [medline]
PHST- 2011/04/01 00:00 [pmc-release]
AID - S1474-4422(10)70040-5 [pii]
AID - 10.1016/S1474-4422(10)70040-5 [doi]
PST - ppublish
SO  - Lancet Neurol. 2010 Apr;9(4):425-37. doi: 10.1016/S1474-4422(10)70040-5.