PMID- 20299683
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20181113
IS  - 1524-4636 (Electronic)
IS  - 1079-5642 (Print)
IS  - 1079-5642 (Linking)
VI  - 30
IP  - 6
DP  - 2010 Jun
TI  - Monocyte chemoattractant protein-1 deficiency protects against visceral 
      fat-induced atherosclerosis.
PG  - 1151-8
LID - 10.1161/ATVBAHA.110.205914 [doi]
AB  - OBJECTIVE: To determine the role of monocyte chemoattractant protein-1 (Mcp-1) on 
      the progression of visceral fat-induced atherosclerosis. METHODS AND RESULTS: 
      Visceral fat inflammation was induced by transplantation of perigonadal fat. To 
      determine whether recipient Mcp-1 status affected atherosclerosis induced by 
      inflammatory fat, apolipoprotein E-deficient (ApoE(-/-)) and ApoE(-/-) and 
      Mcp-1-deficient (Mcp-1(-/-)) mice underwent visceral fat transplantation. 
      Intravital microscopy was used to study leukocyte-endothelial interactions. To 
      study the primary tissue source of circulating Mcp-1, both fat and bone marrow 
      transplantation experiments were used. Transplantation of visceral fat increased 
      atherosclerosis in ApoE(-/-) mice but had no effect on atherosclerosis in 
      ApoE(-/-),Mcp-1(-/-) mice. Intravital microscopy revealed increased leukocyte 
      attachment to the endothelium in ApoE(-/-) mice compared with 
      ApoE(-/-),Mcp-1(-/-) mice after receiving visceral fat transplants. 
      Transplantation of visceral fat increased plasma Mcp-1, although donor adipocytes 
      were not the source of circulating Mcp-1 because no Mcp-1 was detected in plasma 
      from ApoE(-/-),Mcp-1(-/-) mice transplanted with Wt fat, indicating that 
      recipient Mcp-1-producing cells were affecting the atherogenic response to the 
      fat transplantation. Consistently, transplantation of Mcp-1(-/-) fat to ApoE(-/-) 
      mice did not lead to atheroprotection in recipient mice. Bone marrow 
      transplantation between Wt and Mcp-1(-/-) mice indicated that the primary tissue 
      source of circulating Mcp-1 was the endothelium. CONCLUSIONS: Recipient Mcp-1 
      deficiency protects against atherosclerosis induced by transplanted visceral 
      adipose tissue.
FAU - Ohman, Miina K
AU  - Ohman MK
AD  - Cardiovascular Research Center, Department of Internal Medicine, University of 
      Michigan, Ann Arbor, MI 48109-0644, USA.
FAU - Wright, Andrew P
AU  - Wright AP
FAU - Wickenheiser, Kevin J
AU  - Wickenheiser KJ
FAU - Luo, Wei
AU  - Luo W
FAU - Russo, Hana M
AU  - Russo HM
FAU - Eitzman, Daniel T
AU  - Eitzman DT
LA  - eng
GR  - P01 HL057346/HL/NHLBI NIH HHS/United States
GR  - R01 HL073150-06A2/HL/NHLBI NIH HHS/United States
GR  - R01 HL073150/HL/NHLBI NIH HHS/United States
GR  - HL57346/HL/NHLBI NIH HHS/United States
GR  - HL073150/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100318
PL  - United States
TA  - Arterioscler Thromb Vasc Biol
JT  - Arteriosclerosis, thrombosis, and vascular biology
JID - 9505803
RN  - 0 (Apolipoproteins E)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adipocytes/immunology
MH  - Animals
MH  - Apolipoproteins E/deficiency/genetics
MH  - Atherosclerosis/genetics/immunology/metabolism/*prevention & control
MH  - Bone Marrow Transplantation
MH  - Cell Adhesion
MH  - Chemokine CCL2/blood/*deficiency/genetics
MH  - Disease Models, Animal
MH  - Endothelial Cells/*immunology
MH  - Intra-Abdominal Fat/*immunology/transplantation
MH  - Leukocytes/*immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Microscopy, Video
MH  - Panniculitis/complications/*immunology/metabolism
MH  - Time Factors
PMC - PMC2874123
MID - NIHMS198595
EDAT- 2010/03/20 06:00
MHDA- 2010/06/04 06:00
PMCR- 2011/06/01
CRDT- 2010/03/20 06:00
PHST- 2010/03/20 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
PHST- 2011/06/01 00:00 [pmc-release]
AID - ATVBAHA.110.205914 [pii]
AID - 10.1161/ATVBAHA.110.205914 [doi]
PST - ppublish
SO  - Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1151-8. doi: 
      10.1161/ATVBAHA.110.205914. Epub 2010 Mar 18.