PMID- 20302777
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20181201
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 31
IP  - 1
DP  - 2010 Jan
TI  - [Correlation of Bcl-2 with immunological subtype and prognosis in diffuse large 
      B-cell lymphoma.].
PG  - 34-7
AB  - OBJECTIVE: To investigate the Bcl-2 protein and gene expression in diffuse large 
      B-cell lymphoma (DLBCL), and analyze its correlation with immunosubtype and 
      prognosis. METHODS: Seventy-three cases of DLBCL were performed 
      immunohistochemistry analysis with a panel of antibodies CD3, CD10, CD20, Bcl-6, 
      Bcl-2 and MUM-1, and classified into germinal center B-cell (GCB) type and 
      non-GCB type. Fluorescence in situ hybridization (FISH) was employed to detect 
      bcl-2 gene expression in 57 cases with chromosome translocation t (14;18). 
      RESULTS: The percentages of tumor cells expressed CD10, Bcl-6, MUM-1 and Bcl-2 
      were 15.1%, 38.4%, 71.2% and 79.2%, respectively. 16 cases (21.9%) were GCB type 
      and the rest (78.1%) were non-GCB type. 16 of 57 cases (28.1%) were t (14; 18), 
      including 5 of GCB type (31.2%) and 11 of non-GCB type (68.2%). The expression of 
      Bcl-2 protein was correlated with immunological subtype (P = 0.035), but not with 
      survival time (P = 0.253). Between the t(14;18) positive and negtive groupes, 
      there was significant difference for survival time (P = 0.022), but no difference 
      for immunological subtype (P = 0.340). There was no correlation between Bcl-2 
      protein and t(14;18). CONCLUSIONS: GCB type DBLBCL with expression of Bcl-2 
      protein had a poor prognosis. t(14; 18) positive BLBCL had poor prognosis. The 
      expression of Bcl-2 protein and t(14; 18) are usually discordant.
FAU - Xi, Yan-Feng
AU  - Xi YF
AD  - Department of Pathology, Shanxi Tumor Hospital, Taiyuan 030013, China.
FAU - Wang, Guo-Ping
AU  - Wang GP
FAU - Li, Yi
AU  - Li Y
FAU - Wang, Jin-Fen
AU  - Wang JF
FAU - Sun, Rui-Fang
AU  - Sun RF
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
SB  - IM
MH  - Genes, bcl-2
MH  - Germinal Center
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - *Lymphoma, Large B-Cell, Diffuse
MH  - Prognosis
EDAT- 2010/03/23 06:00
MHDA- 2016/04/24 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2010 Jan;31(1):34-7.