PMID- 20302925
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20141120
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 392
IP  - 1-2
DP  - 2010 Jun 15
TI  - The advantages of a novel CoQ10 delivery system in skin photo-protection.
PG  - 57-63
LID - 10.1016/j.ijpharm.2010.03.032 [doi]
AB  - Skin photo-ageing induced by ultraviolet (UV) radiation is mainly ascribed to 
      oxidative stress and reactive oxygen species (ROS). Coenzyme Q10 (CoQ10) has been 
      reported as a powerful antioxidant in plasma. However, CoQ10 was barely 
      satisfactory in topical drug delivery because of its lipid solubility. To improve 
      the anti-oxidative efficiency of CoQ10 in skin photo-ageing, the present research 
      prepared a novel CoQ10 nano-structured lipid carrier (CoQ10-NLC) and 
      characterised it by size and freeze-fracture transmission electron microscopy 
      (FF-TEM). In UVA-irradiated fibroblasts, the protection of CoQ10-NLC was more 
      effective than the CoQ10-emulsion as demonstrated by cell viability and 
      morphological changes of the cell body and nucleus. In addition, malondialdehyde 
      (MDA, the product of lipid peroxidation) concentration decreased by 61.5% in the 
      group treated with CoQ10-NLC compared to the group subjected to general 
      CoQ10-emulsion. In the presence of CoQ10-NLC, the activities of the 
      anti-oxidative enzymes superoxide dismutase (SOD) and glutathione peroxidase 
      (GSH-px) were reinstated to 81% and 75%, respectively, of the control group. In 
      vivo, the CoQ10-NLC displayed a stronger capability to penetrate the stratum 
      corneum and permeate the dermis after a topical skin application. These results 
      reveal that CoQ10-NLC has greater antioxidant properties and topical skin 
      penetration than the CoQ10-emulsion.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Yue, Yang
AU  - Yue Y
AD  - State Key Lab Biomembrane & Membrane Biotechnology, School of Life Sciences, 
      Tsinghua University, Beijing, China.
FAU - Zhou, Huafeng
AU  - Zhou H
FAU - Liu, Guanlan
AU  - Liu G
FAU - Li, Yan
AU  - Li Y
FAU - Yan, Zemin
AU  - Yan Z
FAU - Duan, Mingxing
AU  - Duan M
LA  - eng
PT  - Journal Article
DEP - 20100317
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Drug Carriers)
RN  - 0 (Lipid Peroxides)
RN  - 0 (Lipids)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Sunscreening Agents)
RN  - 1339-63-5 (Ubiquinone)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EJ27X76M46 (coenzyme Q10)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects/radiation effects
MH  - Cells, Cultured
MH  - Drug Carriers/*chemistry
MH  - Female
MH  - Fibroblasts/drug effects/enzymology/metabolism/pathology/radiation effects
MH  - Glutathione Peroxidase/metabolism
MH  - Humans
MH  - Lipid Peroxides/metabolism
MH  - Lipids/*chemistry
MH  - Microscopy, Electron, Transmission
MH  - Models, Biological
MH  - Nanostructures/*chemistry
MH  - Oxidative Stress/drug effects/radiation effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reactive Oxygen Species/metabolism
MH  - Skin/drug effects/enzymology/metabolism/radiation effects
MH  - Skin Absorption/drug effects
MH  - *Skin Aging/drug effects/radiation effects
MH  - Solubility
MH  - Sunscreening Agents/*administration & dosage/chemistry/pharmacokinetics
MH  - Superoxide Dismutase/metabolism
MH  - Surface Properties
MH  - Ubiquinone/administration & dosage/*analogs & 
      derivatives/chemistry/pharmacokinetics
MH  - Ultraviolet Rays/adverse effects
EDAT- 2010/03/23 06:00
MHDA- 2010/09/08 06:00
CRDT- 2010/03/23 06:00
PHST- 2009/09/22 00:00 [received]
PHST- 2010/02/12 00:00 [revised]
PHST- 2010/03/10 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/09/08 06:00 [medline]
AID - S0378-5173(10)00206-1 [pii]
AID - 10.1016/j.ijpharm.2010.03.032 [doi]
PST - ppublish
SO  - Int J Pharm. 2010 Jun 15;392(1-2):57-63. doi: 10.1016/j.ijpharm.2010.03.032. Epub 
      2010 Mar 17.