PMID- 20303018
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20100322
IS  - 1873-4456 (Electronic)
IS  - 0165-4608 (Linking)
VI  - 198
IP  - 1
DP  - 2010 Apr 1
TI  - Detection of cryptic and variant IGH-MYC rearrangements in high-grade 
      non-Hodgkin's lymphoma by fluorescence in situ hybridization: implications for 
      cytogenetic testing.
PG  - 71-5
LID - 10.1016/j.cancergencyto.2009.12.010 [doi]
AB  - In recent years it has become increasingly evident that MYC rearrangements are 
      not confined to classical Burkitt lymphoma (BL), but also occur in diffuse large 
      B-cell lymphoma (DLBCL) and in the new subtype, "B-cell lymphoma, unclassifiable, 
      with features intermediate between DLBCL and BL" (BCLU), which was recently 
      described in the 2008 revision of the World Health Organization classification. 
      The accurate identification of MYC rearrangements in these three subtypes of 
      high-grade lymphoma is becoming increasingly critical both in terms of diagnosis 
      of classical BL and in light of the prognostic implications in cases of DLBCL and 
      BCLU. We describe three cases of high-grade lymphoma in which cryptic insertion 
      events, resulting in clinically significant IGH-MYC rearrangements, were 
      detectable using an IGH/MYC three-color, dual-fusion fluorescence in situ 
      hybridization (FISH) probe set, but were not detected using break-apart MYC FISH 
      probes, thus highlighting the limitations of using break-apart probes as a 
      stand-alone test, particularly with the increased use of interphase FISH analysis 
      of formalin-fixed, paraffin-embedded tissue sections in the diagnostic work-up of 
      these patients.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - May, Philippa C
AU  - May PC
AD  - Department of Haematology and Department of Cytogenetics, GSTS Pathology, Guy's 
      and St. Thomas NHS Foundation Trust, Great Maze Pond, London, SE1 9RT UK.
FAU - Foot, Nicola
AU  - Foot N
FAU - Dunn, Robert
AU  - Dunn R
FAU - Geoghegan, Helen
AU  - Geoghegan H
FAU - Neat, Michael J
AU  - Neat MJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Molecular Probes)
SB  - IM
MH  - Aged
MH  - Female
MH  - *Genes, Immunoglobulin Heavy Chain
MH  - *Genes, myc
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Male
MH  - Middle Aged
MH  - Molecular Probes
MH  - *Translocation, Genetic
EDAT- 2010/03/23 06:00
MHDA- 2010/04/03 06:00
CRDT- 2010/03/23 06:00
PHST- 2009/10/22 00:00 [received]
PHST- 2009/12/15 00:00 [revised]
PHST- 2009/12/15 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - S0165-4608(09)00700-6 [pii]
AID - 10.1016/j.cancergencyto.2009.12.010 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2010 Apr 1;198(1):71-5. doi: 
      10.1016/j.cancergencyto.2009.12.010.