PMID- 20303086
OWN - NLM
STAT- MEDLINE
DCOM- 20100629
LR  - 20240109
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1217
IP  - 16
DP  - 2010 Apr 16
TI  - Determination of pharmaceuticals in environmental and biological matrices using 
      pressurised liquid extraction--are we developing sound extraction methods?
PG  - 2447-70
LID - 10.1016/j.chroma.2010.02.046 [doi]
AB  - Pressurised liquid extraction (PLE) is now a well established and extensively 
      applied extraction technique in environmental analysis for pollutants such as 
      persistent organic pollutants (POPs). During the past decade, an emerging group 
      of environmentally interesting analytes are pharmaceuticals that are continuingly 
      released into the environment. This class is comprised with compounds of various 
      properties. As the field of the analysis of these compounds grows, an increasing 
      number of PLE methods for pharmaceuticals of varying quality are developed and 
      published. This review summarises the critical PLE parameters during PLE method 
      development and highlight them with examples from recently published papers 
      utilising pressurised liquid extraction for the determination of pharmaceuticals 
      in environmental and biological matrices. These recent methods are summarised and 
      critically discussed with the aim to provide important reflections to alleviate 
      in future PLE development for pharmaceuticals in environmental matrices.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Runnqvist, Hannah
AU  - Runnqvist H
AD  - Section of Toxicology and Environmental Chemistry, Department of Pharmaceutics 
      and Analytical Chemistry, Faculty of Pharmaceutical Sciences, Copenhagen 
      University, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
FAU - Bak, Soren Alex
AU  - Bak SA
FAU - Hansen, Martin
AU  - Hansen M
FAU - Styrishave, Bjarne
AU  - Styrishave B
FAU - Halling-Sorensen, Bent
AU  - Halling-Sorensen B
FAU - Bjorklund, Erland
AU  - Bjorklund E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100226
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Solvents)
SB  - IM
MH  - Chemical Fractionation/*methods
MH  - Pharmaceutical Preparations/*analysis/chemistry
MH  - Pressure
MH  - Solvents/chemistry
MH  - Temperature
RF  - 109
EDAT- 2010/03/23 06:00
MHDA- 2010/06/30 06:00
CRDT- 2010/03/23 06:00
PHST- 2009/12/14 00:00 [received]
PHST- 2010/02/18 00:00 [revised]
PHST- 2010/02/19 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/06/30 06:00 [medline]
AID - S0021-9673(10)00265-7 [pii]
AID - 10.1016/j.chroma.2010.02.046 [doi]
PST - ppublish
SO  - J Chromatogr A. 2010 Apr 16;1217(16):2447-70. doi: 10.1016/j.chroma.2010.02.046. 
      Epub 2010 Feb 26.