PMID- 20303464
OWN - NLM
STAT- MEDLINE
DCOM- 20100409
LR  - 20220310
IS  - 1878-1810 (Electronic)
IS  - 1878-1810 (Linking)
VI  - 155
IP  - 4
DP  - 2010 Apr
TI  - Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a 
      case-control study.
PG  - 166-9
LID - 10.1016/j.trsl.2009.09.012 [doi]
AB  - Recent data have implicated leukocyte telomere length shortening as a potential 
      risk predictor for type 2 diabetes mellitus (T2DM) and its associated phenotypes. 
      However, to date, epidemiologic data are scarce. Using a case-control study from 
      a community-based population sample of the Boston metropolitan area (all whites: 
      424 controls and 432 cases), we examined the relationship of mean leukocyte 
      telomere repeat copy number to single gene copy number (TSR) and T2DM. 
      Associations of log(e)-transformed TSR with age, race, sex, body mass index 
      (BMI), current smoking status, fasting insulin levels, fasting glucose levels, 
      and hemoglobin A1c (HbA1c) were examined by multivariable linear regression 
      analysis. A logistic regression analysis was performed to evaluate the 
      association of log(e)-transformed TSR with T2DM with or without adjustment for 
      potential confounders. The log(e)-transformed TSR was significantly shorter in 
      the white cases than the white controls (P=0.003). In a multivariable linear 
      regression analysis, an inverse association of log(e)-transformed TSR with BMI 
      was observed (P=0.04). Furthermore, in a multivariable logistic regression 
      analysis, decreased log(e)-transformed TSR was significantly associated with T2DM 
      (adjusted odds ratio=1.748; 95% confidence interval [CI]=1.015-3.012; P=0.044). 
      In summary, the current investigation has shown an association of mean leukocyte 
      telomere length shortening with T2DM in white subjects. If corroborated in other 
      studies, our findings suggest the potential importance of telomere biology in 
      T2DM.
FAU - Zee, Robert Y L
AU  - Zee RY
AD  - Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical 
      School, Boston, MA, USA.
FAU - Castonguay, Amy J
AU  - Castonguay AJ
FAU - Barton, Nathaniel S
AU  - Barton NS
FAU - Germer, Soren
AU  - Germer S
FAU - Martin, Mitchell
AU  - Martin M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091022
PL  - United States
TA  - Transl Res
JT  - Translational research : the journal of laboratory and clinical medicine
JID - 101280339
SB  - IM
CIN - Transl Res. 2010 Apr;155(4):164-5. PMID: 20303463
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/genetics/*metabolism
MH  - Female
MH  - Gene Dosage/genetics
MH  - Humans
MH  - Leukocytes/*metabolism
MH  - Linear Models
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Telomere/genetics/*metabolism
EDAT- 2010/03/23 06:00
MHDA- 2010/04/10 06:00
CRDT- 2010/03/23 06:00
PHST- 2009/09/01 00:00 [received]
PHST- 2009/09/23 00:00 [revised]
PHST- 2009/09/30 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/04/10 06:00 [medline]
AID - S1931-5244(09)00299-0 [pii]
AID - 10.1016/j.trsl.2009.09.012 [doi]
PST - ppublish
SO  - Transl Res. 2010 Apr;155(4):166-9. doi: 10.1016/j.trsl.2009.09.012. Epub 2009 Oct 
      22.