PMID- 20304050
OWN - NLM
STAT- MEDLINE
DCOM- 20100909
LR  - 20131121
IS  - 1873-3441 (Electronic)
IS  - 0939-6411 (Linking)
VI  - 75
IP  - 2
DP  - 2010 Jun
TI  - Active packaging for topical cosmetic/drug products: a hot-melt extruded 
      preservative delivery device.
PG  - 291-6
LID - 10.1016/j.ejpb.2010.03.007 [doi]
AB  - A delivery device intended for the prolonged release of antimicrobial agents, 
      able to enhance the stability profile of liquid/semi-solid 
      cosmetic/pharmaceutical products for topical application, was proposed in the 
      present study. With the aid of a simulation program based on compartment models, 
      the relevant kinetic and formulation parameters were defined using dehydroacetic 
      acid sodium salt (DHA.Na, Prevan) as the model preservative. Indeed, the overall 
      DHA.Na degradation rate is increased in the presence of formaldehyde releasers 
      that are often employed as co-preservatives. Inert matrices (3 g weight and 18 mm 
      diameter) based on high-density polyethylene (HDPE), possibly consistent with the 
      design of an active packaging meant for preservative delivery, were prepared by 
      hot-melt extrusion. Units with satisfactory physical-technological properties 
      could be obtained up to 50%w/w loads of antimicrobial agent. In an attempt to 
      modify the relevant Fickian release profiles by varying the area exposed to the 
      medium, matrix systems coated with an impermeable film except for one base (CMs) 
      or for the inner surface of a central drilled hole (PCMs) were investigated. On 
      the basis of the n exponent of power equation and the outcome of linear fitting, 
      PCMs were proven able to yield the zero-order release behaviour needed to ensure 
      constant DHA.Na levels over a predetermined time period, as indicated by the 
      simulation process.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Zema, L
AU  - Zema L
AD  - Dipartimento di Scienze Farmaceutiche P. Pratesi, Universita degli Studi di 
      Milano, Milano, Italy. lucia.zema@unimi.it
FAU - Sangalli, M E
AU  - Sangalli ME
FAU - Maroni, A
AU  - Maroni A
FAU - Foppoli, A
AU  - Foppoli A
FAU - Bettero, A
AU  - Bettero A
FAU - Gazzaniga, A
AU  - Gazzaniga A
LA  - eng
PT  - Journal Article
DEP - 20100318
PL  - Netherlands
TA  - Eur J Pharm Biopharm
JT  - European journal of pharmaceutics and biopharmaceutics : official journal of 
      Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
JID - 9109778
RN  - 0 (Cosmetics)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Preservatives, Pharmaceutical)
RN  - 0 (Pyrones)
RN  - 1HG84L3525 (Formaldehyde)
RN  - 2KAG279R6R (dehydroacetic acid)
RN  - 9002-88-4 (Polyethylene)
SB  - IM
MH  - Administration, Cutaneous
MH  - Computer Simulation
MH  - Cosmetics/*chemistry
MH  - Delayed-Action Preparations
MH  - *Drug Delivery Systems
MH  - Drug Packaging
MH  - Drug Stability
MH  - Formaldehyde/chemistry
MH  - Hot Temperature
MH  - Polyethylene/chemistry
MH  - Preservatives, Pharmaceutical/*chemistry
MH  - Pyrones/*chemistry
MH  - Time Factors
EDAT- 2010/03/23 06:00
MHDA- 2010/09/10 06:00
CRDT- 2010/03/23 06:00
PHST- 2009/11/06 00:00 [received]
PHST- 2010/03/02 00:00 [revised]
PHST- 2010/03/15 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/09/10 06:00 [medline]
AID - S0939-6411(10)00065-2 [pii]
AID - 10.1016/j.ejpb.2010.03.007 [doi]
PST - ppublish
SO  - Eur J Pharm Biopharm. 2010 Jun;75(2):291-6. doi: 10.1016/j.ejpb.2010.03.007. Epub 
      2010 Mar 18.