PMID- 20304401
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20161125
IS  - 1097-6779 (Electronic)
IS  - 0016-5107 (Linking)
VI  - 71
IP  - 7
DP  - 2010 Jun
TI  - EUS for pancreatic neuroendocrine tumors: a single-center, 11-year experience.
PG  - 1185-93
LID - 10.1016/j.gie.2009.12.006 [doi]
AB  - BACKGROUND: Pancreatic neuroendocrine tumors (PNTs) are rare tumors with 
      malignant potential. EUS and EUS-guided FNA (EUS-FNA) have been shown to be 
      superior to other imaging methods in the preoperative localization and diagnosis 
      of PNTs. OBJECTIVES: To evaluate the clinical presentation, EUS morphology, and 
      sensitivity of EUS-FNA cytology in a large consecutive cohort with histologically 
      and/or cytologically confirmed PNTs. DESIGN: Retrospective study of all 
      consecutive patients from July 1995 to November 2006 who underwent EUS for a 
      known or suspected PNT and had a subsequently histologically confirmed PNT. 
      SETTING: Tertiary referral center. PATIENTS: Ninety-two patients with suspected 
      PNT. INTERVENTIONS: EUS evaluation with or without EUS-FNA of PNTs. MAIN OUTCOME 
      MEASUREMENTS: Clinical and EUS features of PNTs and sensitivity of EUS-FNA for 
      the diagnosis of PNTs. RESULTS: Ninety-two patients underwent EUS; 76 patients 
      had confirmed histopathology, of whom 69 (91%) were symptomatic. Patients with 
      functional PNTs presented with diarrhea, peptic ulcer disease, and hypoglycemia. 
      Tumor locations and echogenic features were similar except that nonfunctional 
      PNTs tended to be larger and have cystic features. Patients with malignant PNTs 
      were older (P = .03), presented with abdominal pain, and had larger tumors (P = 
      .0006) with irregular margins. Eighty-nine percent of patients underwent EUS-FNA. 
      Sensitivity of EUS-FNA for the diagnosis of a PNT was 87%. Sensitivity of EUS-FNA 
      was similar in functional and nonfunctional PNTs. The sensitivity of EUS-FNA was 
      higher for malignant PNTs (P = .008). LIMITATIONS: Retrospective single tertiary 
      center. CONCLUSIONS: EUS and EUS-FNA are sensitive tools, especially in cases of 
      suspected symptomatic PNTs in which other imaging modalities have failed.
CI  - Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by 
      Mosby, Inc. All rights reserved.
FAU - Pais, Shireen A
AU  - Pais SA
AD  - Sarah C. Upham Division of Gastroenterology and Hepatobiliary diseases, New York 
      Medical College, Valhalla, New York, USA.
FAU - Al-Haddad, Mohammad
AU  - Al-Haddad M
FAU - Mohamadnejad, Mehdi
AU  - Mohamadnejad M
FAU - Leblanc, Julia K
AU  - Leblanc JK
FAU - Sherman, Stuart
AU  - Sherman S
FAU - McHenry, Lee
AU  - McHenry L
FAU - DeWitt, John M
AU  - DeWitt JM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100320
PL  - United States
TA  - Gastrointest Endosc
JT  - Gastrointestinal endoscopy
JID - 0010505
SB  - IM
MH  - Adult
MH  - Biopsy, Fine-Needle/methods
MH  - Diagnosis, Differential
MH  - Endosonography/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuroendocrine Tumors/*diagnostic imaging/pathology
MH  - Pancreatic Neoplasms/*diagnostic imaging/pathology
MH  - Preoperative Period
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Young Adult
EDAT- 2010/03/23 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/03/23 06:00
PHST- 2009/07/22 00:00 [received]
PHST- 2009/12/03 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - S0016-5107(09)02860-0 [pii]
AID - 10.1016/j.gie.2009.12.006 [doi]
PST - ppublish
SO  - Gastrointest Endosc. 2010 Jun;71(7):1185-93. doi: 10.1016/j.gie.2009.12.006. Epub 
      2010 Mar 20.