PMID- 20306445
OWN - NLM
STAT- MEDLINE
DCOM- 20101006
LR  - 20221207
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 20
IP  - 5
DP  - 2010 Sep-Oct
TI  - Familial clustering of diabetic retinopathy in Chongqing, China, type 2 diabetic 
      patients.
PG  - 911-8
AB  - PURPOSE: To investigate whether there is familial aggregation of diabetic 
      retinopathy (DR) among type 2 diabetes mellitus (T2DM) patients in Chongqing, the 
      municipality in southwest China. METHODS: From December 2004 to December 2006, 
      167 T2DM families with at least 2 diabetic siblings were investigated. In all 414 
      subjects, the sibling with the longest duration of diabetes was defined as the 
      proband. The occurrence of retinopathy was compared between the siblings of 
      probands with and without retinopathy. DR risk factors of the siblings of 
      probands were studied by multiple logistic regression analysis. RESULTS: DR was 
      diagnosed in 7.1% of the siblings of the probands without DR and in 29.7% of the 
      siblings of the probands with DR. The difference reached statistical significance 
      in probands with DR and probands without DR (p<0.0001). Nonesterified fatty acid 
      (NEFA) was a risk factor for DR (odds ratio = 2.108, 95% confidence interval 
      1.077-4.127). It appeared that regardless of probands with DR, siblings with 
      history of smoking had less risk for developing DR than those with no history of 
      smoking. CONCLUSIONS: Familial clustering of DR existed in the patients with T2DM 
      in Chongqing, China. In DR siblings, NEFA is a risk factor of DR, while smoking 
      may reduce DR occurrence.
FAU - Zhang, Xuedong
AU  - Zhang X
AD  - Department of Ophthalmology, The 1st Affiliated Hospital, Chongqing Medical 
      University, Chongqing Key Laboratory of Ophthalmology, Chongqing, China. 
      zxued@sina.com
FAU - Gao, Yan
AU  - Gao Y
FAU - Zhou, Zhongqiang
AU  - Zhou Z
FAU - Wang, Jing
AU  - Wang J
FAU - Zhou, Qingyun
AU  - Zhou Q
FAU - Li, Qi
AU  - Li Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
SB  - IM
MH  - Asian People/*genetics
MH  - Blood Glucose/analysis
MH  - China/epidemiology
MH  - Cluster Analysis
MH  - Diabetes Mellitus, Type 2/epidemiology/*genetics
MH  - Diabetic Retinopathy/epidemiology/*genetics
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Risk Factors
MH  - Siblings
MH  - Smoking/epidemiology
EDAT- 2010/03/23 06:00
MHDA- 2010/10/07 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/10/07 06:00 [medline]
AID - 65180F2A-12C2-4536-910E-149EFA57805B [pii]
AID - 10.1177/112067211002000516 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2010 Sep-Oct;20(5):911-8. doi: 10.1177/112067211002000516.