PMID- 20306665
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20161021
IS  - 1110-4902 (Print)
VI  - 15
IP  - 1
DP  - 2008
TI  - Psychiatric morbidity associated with some cytokines (IL-1beta, IL-12, IL-18 and 
      TNF-alpha) among rheumatoid arthritis patients.
PG  - 1-11
AB  - Psychiatric morbidity is common in rheumatoid arthritis (RA) patients and may 
      affect disease activity and immunological markers. We studied the relationship of 
      the psychiatric morbidity and immunological factors; the serum levels of 
      Interleukin-1beta (IL-1beta), Tumor Necrosis Factor Alpha (TNF-alpha), 
      Interleukin-18 (IL-18) and its inducer interleukin-12 (IL-12), and their impact 
      on RA disease activity. Forty-two RA patients and 20 apparently healthy 
      individuals as a control group were included in this study. Psychiatric morbidity 
      was identified according to the International Classification of Disease, tenth 
      version criteria (ICD-10). The Hospital Anxiety and Depression Scale (HADS) and 
      the mental health Short Form 36 (SF-36) were applied for further analysis. Serum 
      IL-1beta, IL-12, IL-18 and the TNF-a were measured using Enzyme-Amplified 
      Sensitivity Immunoassays (EASIA) and were correlated with psychiatric morbidity 
      and disease activity as measured by Health Assessment Questionnaire and Overall 
      Status. Psychiatric morbidity was found in 40.48% of the studied patients, the 
      most common psychiatric disorders among RA patients were depressive disorders and 
      anxiety disorders. The SF-36 score was closely correlated to the anxiety and 
      depression score (P < 0.001). RA patients showed high levels of IL-1beta, IL-12, 
      IL-18 and TNF-alpha than the control group. There was a significant correlation 
      between psychiatric morbidity, serum levels of IL-1beta, IL-12, IL-18, TNF-alpha 
      and disease activity measurements. We have to view rheumatoid arthritis as a 
      psycho-immumological disorder rather than an autoimmune disease. Furthermore, the 
      studied cytokines may be a novel target for therapeutic intervention of 
      rheumatoid arthritis and its psychiatric morbidity.
FAU - El-Tantawy, Ashraf M
AU  - El-Tantawy AM
AD  - Department of Psychiatry, Faculty of Medicine, Suez Canal University, Egypt.
FAU - El-Sayed, Abeer E
AU  - El-Sayed AE
FAU - Kora, Bothina A
AU  - Kora BA
FAU - Amin, Ragy T
AU  - Amin RT
LA  - eng
PT  - Journal Article
PL  - Egypt
TA  - Egypt J Immunol
JT  - The Egyptian journal of immunology
JID - 9816016
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Adult
MH  - Anxiety Disorders/blood/diagnosis/epidemiology
MH  - Arthritis, Rheumatoid/*blood/complications/diagnosis
MH  - Cytokines/blood
MH  - Depressive Disorder/blood/diagnosis/epidemiology
MH  - Egypt/epidemiology
MH  - Female
MH  - Humans
MH  - Interleukin-12/*blood
MH  - Interleukin-18/*blood
MH  - Interleukin-1beta/*blood
MH  - Male
MH  - Mental Disorders/*blood/complications/*epidemiology
MH  - Middle Aged
MH  - Morbidity
MH  - Quality of Life
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2008/01/01 00:00
MHDA- 2010/04/22 06:00
CRDT- 2010/03/24 06:00
PHST- 2010/03/24 06:00 [entrez]
PHST- 2008/01/01 00:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
PST - ppublish
SO  - Egypt J Immunol. 2008;15(1):1-11.