PMID- 20307661
OWN - NLM
STAT- MEDLINE
DCOM- 20100920
LR  - 20231105
IS  - 1879-1220 (Electronic)
IS  - 0960-0760 (Print)
IS  - 0960-0760 (Linking)
VI  - 121
IP  - 1-2
DP  - 2010 Jul
TI  - Association between polymorphic variation in VDR and RXRA and circulating levels 
      of vitamin D metabolites.
PG  - 438-41
LID - 10.1016/j.jsbmb.2010.03.052 [doi]
AB  - The vitamin D metabolite 1,25(OH)2D is the bioactive ligand of the vitamin D 
      receptor (VDR). VDR forms a heterodimer with the retinoid X receptors (RXRs) that 
      when bound to ligand influences the transcriptional control of genes that 
      regulate circulating levels of vitamin D metabolites. Whether genetic variation 
      in VDR or RXRA affects circulating levels of 1,25(OH)2D or 25(OH)D has not been 
      established. We used a single nucleotide polymorphism (SNP) tagging approach to 
      evaluate the association between SNPs in VDR and RXRA and serum levels of 
      1,25(OH)2D and 25(OH)D. A total of 42 tagSNPs in VDR and 32 in RXRA were analyzed 
      in a sample of 415 participants. Principal components analyses revealed a 
      gene-level association between RXRA and serum 1,25(OH)2D concentrations (P=0.01), 
      but not 25(OH)D. No gene-level association was found for VDR with either serum 
      biomarker. At the single-SNP level, a significant positive trend was observed for 
      increasing 1,25(OH)2D levels with each additional copy of the A allele for RXRA 
      SNP rs9409929 (P-trend=0.003). After a multiple comparisons adjustment, no 
      individual SNP in VDR or RXRA was significantly associated with either outcome. 
      These results demonstrate an association between genetic variation in RXRA and 
      1,25(OH)2D serum concentrations.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Hibler, E A
AU  - Hibler EA
AD  - Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of 
      Public Health, University of Arizona, Tucson, AZ 85724, USA. 
      ehibler@email.arizona.edu
FAU - Jurutka, P W
AU  - Jurutka PW
FAU - Egan, J B
AU  - Egan JB
FAU - Hu, C
AU  - Hu C
FAU - LeRoy, E C
AU  - LeRoy EC
FAU - Martinez, M E
AU  - Martinez ME
FAU - Thompson, P A
AU  - Thompson PA
FAU - Jacobs, E T
AU  - Jacobs ET
LA  - eng
GR  - K07 CA106269/CA/NCI NIH HHS/United States
GR  - K07 CA106269-01A1/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20100320
PL  - England
TA  - J Steroid Biochem Mol Biol
JT  - The Journal of steroid biochemistry and molecular biology
JID - 9015483
RN  - 0 (Biomarkers)
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (Retinoid X Receptor alpha)
RN  - 1406-16-2 (Vitamin D)
RN  - FXC9231JVH (Calcitriol)
RN  - P6YZ13C99Q (Calcifediol)
SB  - IM
MH  - Biomarkers/blood
MH  - Calcifediol/metabolism
MH  - Calcitriol/metabolism
MH  - Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Models, Biological
MH  - Models, Genetic
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Principal Component Analysis
MH  - Receptors, Calcitriol/*genetics/*metabolism
MH  - Retinoid X Receptor alpha/*genetics/*metabolism
MH  - Transcription, Genetic
MH  - Vitamin D/*blood/*metabolism
PMC - PMC2906637
MID - NIHMS191139
EDAT- 2010/03/24 06:00
MHDA- 2010/09/21 06:00
PMCR- 2011/07/01
CRDT- 2010/03/24 06:00
PHST- 2009/10/30 00:00 [received]
PHST- 2010/03/10 00:00 [revised]
PHST- 2010/03/12 00:00 [accepted]
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - S0960-0760(10)00151-2 [pii]
AID - 10.1016/j.jsbmb.2010.03.052 [doi]
PST - ppublish
SO  - J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):438-41. doi: 
      10.1016/j.jsbmb.2010.03.052. Epub 2010 Mar 20.