PMID- 20308529
OWN - NLM
STAT- MEDLINE
DCOM- 20100630
LR  - 20211020
IS  - 1945-7170 (Electronic)
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 151
IP  - 6
DP  - 2010 Jun
TI  - The nuclear receptor cofactor receptor-interacting protein 140 is a positive 
      regulator of amphiregulin expression and cumulus cell-oocyte complex expansion in 
      the mouse ovary.
PG  - 2923-32
LID - 10.1210/en.2010-0081 [doi]
AB  - The nuclear receptor cofactor receptor-interacting protein 140 (RIP140) is 
      essential for cumulus cell-oocyte complex (COC) expansion, follicular rupture, 
      and oocyte release during ovulation. The expression of many genes necessary for 
      COC expansion is impaired in the absence of RIP140, but the studies herein 
      document that their expression can be restored and COC expansion rescued by 
      treatment with the epidermal growth factor (EGF)-like factor amphiregulin (AREG) 
      both in vitro and in vivo. We demonstrate by several approaches that RIP140 is 
      required for the expression of the EGF-like factors in granulosa cells, but the 
      dependence of genes involved in cumulus expansion, including Ptgs2 Has2, Tnfaip6, 
      and Ptx3, is indirect because they are induced by AREG. Treatment of granulosa 
      cells with forskolin to mimic the effects of LH increases AREG promoter activity 
      in a RIP140-dependent manner that 1) requires an intact cAMP response element in 
      the proximal promoter region of the Areg gene and 2) involves its actions as a 
      coactivator for cAMP response element-binding protein/c-Jun transcription 
      factors. Although human chorionic gonadotropin and AREG coadministration is 
      sufficient to restore ovulation fully in RIP140 heterozygous mice in vivo, both 
      follicular rupture and ovulation remain impaired in the RIP140 null mice. Thus, 
      we conclude that although the level of RIP140 expression in the ovary is a 
      crucial factor required for the transient expression of EGF-like factors 
      necessary for cumulus expansion, it also plays a role in other signaling pathways 
      that induce follicular rupture.
FAU - Nautiyal, Jaya
AU  - Nautiyal J
AD  - Molecular Endocrinology Laboratory, Institute of Reproductive and Developmental 
      Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 
      0NN, United Kingdom.
FAU - Steel, Jennifer H
AU  - Steel JH
FAU - Rosell, Meritxell M
AU  - Rosell MM
FAU - Nikolopoulou, Evanthia
AU  - Nikolopoulou E
FAU - Lee, Kevin
AU  - Lee K
FAU - Demayo, Francesco J
AU  - Demayo FJ
FAU - White, Roger
AU  - White R
FAU - Richards, Joanne S
AU  - Richards JS
FAU - Parker, Malcolm G
AU  - Parker MG
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 079200/Z/06/Z/WT_/Wellcome Trust/United Kingdom
GR  - BB/C504327/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100322
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (AREG protein, human)
RN  - 0 (Amphiregulin)
RN  - 0 (Areg protein, mouse)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (EGF Family of Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Nuclear Receptor Co-Repressor 1)
RN  - 1F7A44V6OU (Colforsin)
SB  - IM
MH  - Amphiregulin
MH  - Animals
MH  - Blotting, Western
MH  - Cells, Cultured
MH  - Chromatin Immunoprecipitation
MH  - Colforsin/pharmacology
MH  - Cumulus Cells/*cytology/drug effects
MH  - Cyclic AMP Response Element-Binding Protein/genetics
MH  - EGF Family of Proteins
MH  - Female
MH  - Genes, jun/genetics
MH  - Glycoproteins/*metabolism/pharmacology
MH  - Granulosa Cells/cytology/drug effects
MH  - In Situ Hybridization
MH  - Intercellular Signaling Peptides and Proteins/*metabolism/pharmacology
MH  - Mice
MH  - Mice, Knockout
MH  - Nuclear Receptor Co-Repressor 1/genetics/*metabolism
MH  - Oocytes/*cytology/drug effects
MH  - Ovary/drug effects/*metabolism
MH  - Promoter Regions, Genetic/genetics
MH  - Protein Binding/genetics/physiology
MH  - RNA Interference
PMC - PMC2875814
EDAT- 2010/03/24 06:00
MHDA- 2010/07/01 06:00
PMCR- 2010/06/01
CRDT- 2010/03/24 06:00
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/07/01 06:00 [medline]
PHST- 2010/06/01 00:00 [pmc-release]
AID - en.2010-0081 [pii]
AID - 5355 [pii]
AID - 10.1210/en.2010-0081 [doi]
PST - ppublish
SO  - Endocrinology. 2010 Jun;151(6):2923-32. doi: 10.1210/en.2010-0081. Epub 2010 Mar 
      22.