PMID- 20309010
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20211020
IS  - 1440-1711 (Electronic)
IS  - 0818-9641 (Print)
IS  - 0818-9641 (Linking)
VI  - 88
IP  - 4
DP  - 2010 May-Jun
TI  - Dendritic cells and humoral immunity in humans.
PG  - 376-80
LID - 10.1038/icb.2010.28 [doi]
AB  - Dendritic cells (DCs) orchestrate the innate and adaptive immune systems to 
      induce tolerance and immunity. DC plasticity and subsets are prominent 
      determinants in the regulation of immune responses. Our recent studies suggest 
      that humoral and cellular immunity is regulated by different myeloid DC subsets 
      with distinct intrinsic properties in humans. Although antibody response is 
      preferentially mediated by CD14(+) dermal DCs, cytotoxic T-cell response is 
      preferentially mediated by Langerhans cells (LCs). Thus, mechanisms whereby DCs 
      induce humoral and cellular immunity seem to be fundamentally distinct. In this 
      review, we will focus on the role of DCs in the development of humoral immunity. 
      We will also discuss the mechanisms whereby DCs induce CD4(+) T cells associated 
      with aiding B-cell response, including T follicular helper (Tfh) cells, and why 
      human LCs lack this ability.
FAU - Ueno, Hideki
AU  - Ueno H
AD  - Baylor Institute for Immunology Research and INSERM U899, Dallas, TX 75204, USA. 
      HidekiU@BaylorHealth.edu
FAU - Schmitt, Nathalie
AU  - Schmitt N
FAU - Palucka, A Karolina
AU  - Palucka AK
FAU - Banchereau, Jacques
AU  - Banchereau J
LA  - eng
GR  - P01 CA084512-05A29004/CA/NCI NIH HHS/United States
GR  - P01 CA084512-07S1/CA/NCI NIH HHS/United States
GR  - P01 CA084512-020003/CA/NCI NIH HHS/United States
GR  - R01 CA078846-01A1/CA/NCI NIH HHS/United States
GR  - U19 AI057234-010004/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-06S3/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-010005/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-06S25842/AI/NIAID NIH HHS/United States
GR  - P01 CA084512-069004/CA/NCI NIH HHS/United States
GR  - U19 AI057234-06S37751/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-04/AI/NIAID NIH HHS/United States
GR  - R01 CA089440-04/CA/NCI NIH HHS/United States
GR  - R01 CA089440-02/CA/NCI NIH HHS/United States
GR  - U19 AI057234-02/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-05S10012/AI/NIAID NIH HHS/United States
GR  - R01 CA089440-01A1/CA/NCI NIH HHS/United States
GR  - P01 CA084512-060005/CA/NCI NIH HHS/United States
GR  - R01 CA078846-04/CA/NCI NIH HHS/United States
GR  - U19 AI057234-06S28130/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-01/AI/NIAID NIH HHS/United States
GR  - P01 CA084512-01A10003/CA/NCI NIH HHS/United States
GR  - U19 AI057234-06S1/AI/NIAID NIH HHS/United States
GR  - P01 CA084512-030003/CA/NCI NIH HHS/United States
GR  - U19 AI057234-06S28136/AI/NIAID NIH HHS/United States
GR  - P01 CA084512-05A2/CA/NCI NIH HHS/United States
GR  - R01 CA078846-05/CA/NCI NIH HHS/United States
GR  - U19 AI057234-065842/AI/NIAID NIH HHS/United States
GR  - R01 CA078846-07/CA/NCI NIH HHS/United States
GR  - R01 CA078846-08/CA/NCI NIH HHS/United States
GR  - P01 CA084512-079004/CA/NCI NIH HHS/United States
GR  - U19 AI057234-068130/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-05/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-068137/AI/NIAID NIH HHS/United States
GR  - P01 CA084512/CA/NCI NIH HHS/United States
GR  - U19 AI057234-06S28137/AI/NIAID NIH HHS/United States
GR  - R01 CA078846-10/CA/NCI NIH HHS/United States
GR  - P01 CA084512-06/CA/NCI NIH HHS/United States
GR  - R01 CA078846-06/CA/NCI NIH HHS/United States
GR  - U19 AI057234-010006/AI/NIAID NIH HHS/United States
GR  - P01 CA084512-079002/CA/NCI NIH HHS/United States
GR  - P01 CA084512-069002/CA/NCI NIH HHS/United States
GR  - U19 AI057234-05S19003/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-06/AI/NIAID NIH HHS/United States
GR  - R01 CA078846-09/CA/NCI NIH HHS/United States
GR  - U19 AI057234-05S1/AI/NIAID NIH HHS/United States
GR  - CA078846/CA/NCI NIH HHS/United States
GR  - U19 AI082715-017349/AI/NIAID NIH HHS/United States
GR  - R01 CA078846-02/CA/NCI NIH HHS/United States
GR  - U19 AI057234/AI/NIAID NIH HHS/United States
GR  - R01 CA089440/CA/NCI NIH HHS/United States
GR  - U19 AI057234-06S2/AI/NIAID NIH HHS/United States
GR  - P01 CA084512-05A29002/CA/NCI NIH HHS/United States
GR  - U19 AI057234-03/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-06S17749/AI/NIAID NIH HHS/United States
GR  - R01 CA089440-03/CA/NCI NIH HHS/United States
GR  - R01 CA078846-03/CA/NCI NIH HHS/United States
GR  - R01 CA078846/CA/NCI NIH HHS/United States
GR  - P01 CA084514/CA/NCI NIH HHS/United States
GR  - U19 AI057234-05S10013/AI/NIAID NIH HHS/United States
GR  - U19 AI082715/AI/NIAID NIH HHS/United States
GR  - U19 AI057234-068136/AI/NIAID NIH HHS/United States
GR  - P01 CA084512-070005/CA/NCI NIH HHS/United States
GR  - P01 CA084512-07/CA/NCI NIH HHS/United States
GR  - P01 CA084512-040003/CA/NCI NIH HHS/United States
GR  - P01 CA084512-05A20005/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100323
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
SB  - IM
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - *Immunity, Humoral
MH  - Lymphocytes/immunology
PMC - PMC2865578
MID - NIHMS191206
EDAT- 2010/03/24 06:00
MHDA- 2010/08/25 06:00
PMCR- 2011/05/01
CRDT- 2010/03/24 06:00
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
PHST- 2011/05/01 00:00 [pmc-release]
AID - icb201028 [pii]
AID - 10.1038/icb.2010.28 [doi]
PST - ppublish
SO  - Immunol Cell Biol. 2010 May-Jun;88(4):376-80. doi: 10.1038/icb.2010.28. Epub 2010 
      Mar 23.