PMID- 20309529
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20211020
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 210
IP  - 1
DP  - 2010 May
TI  - Reinstatement of extinguished amphetamine self-administration by 
      3,4-methylenedioxymethamphetamine (MDMA) and its enantiomers in rhesus monkeys.
PG  - 75-83
LID - 10.1007/s00213-010-1818-7 [doi]
AB  - RATIONALE: The effectiveness of MDMA and its enantiomers to reinstate responding 
      previously maintained by drug self-administration has not been thoroughly 
      investigated. OBJECTIVES: The present study was designed to compare the 
      reinstatement effects of amphetamine, the piperazine-analog BZP, SR(+/-)-MDMA, 
      S(+)-MDMA, R(-)-MDMA, and fenfluramine on behavior maintained under a 
      second-order schedule of intravenous amphetamine self-administration in rhesus 
      monkeys (n=4). METHODS: Following saline substitution and extinction, a range of 
      doses of amphetamine, BZP, SR(+/-)-MDMA, S(+)-MDMA, R(-)-MDMA, and fenfluramine 
      were administered i.v. as non-contingent priming injections in order to 
      characterize their effectiveness to reinstate responding previously maintained by 
      amphetamine self-administration. RESULTS: Priming injections of amphetamine, BZP, 
      SR(+/-)-MDMA, and S(+)-MDMA induced significant reinstatement effects. In 
      contrast, neither R(-)-MDMA nor fenfluramine effectively reinstated behavior. 
      Pretreatment with the selective serotonin transporter inhibitor, fluoxetine, 
      attenuated the reinstatement effects of SR(+/-)-MDMA, S(+)-MDMA, and BZP but had 
      no significant effect on amphetamine-primed reinstatement. CONCLUSIONS: Given the 
      profile of neurochemical effects published previously, these findings suggest 
      that the reinstatement effects of MDMA are mediated primarily by dopamine 
      release; however, the attenuation of MDMA-induced reinstatement by fluoxetine 
      supports previous research demonstrating the complex behavioral pharmacology of 
      MDMA-like drugs and that the reinstatement effects of MDMA are at least partially 
      mediated by serotonergic mechanisms.
FAU - McClung, Jessica
AU  - McClung J
AD  - Division of Neuroscience, Yerkes National Primate Research Center, Emory 
      University, Atlanta, GA, USA.
FAU - Fantegrossi, William
AU  - Fantegrossi W
FAU - Howell, Leonard L
AU  - Howell LL
LA  - eng
GR  - K02 DA000517/DA/NIDA NIH HHS/United States
GR  - K02 DA000517-10/DA/NIDA NIH HHS/United States
GR  - R37 DA010344/DA/NIDA NIH HHS/United States
GR  - R37 DA010344-13/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
DEP - 20100323
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amphetamine/*administration & dosage
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Macaca mulatta
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/*analogs & 
      derivatives
MH  - Reaction Time/drug effects/physiology
MH  - *Reinforcement Schedule
MH  - Self Administration
MH  - Stereoisomerism
PMC - PMC2862592
MID - NIHMS196550
EDAT- 2010/03/24 06:00
MHDA- 2010/12/14 06:00
PMCR- 2011/05/01
CRDT- 2010/03/24 06:00
PHST- 2009/10/29 00:00 [received]
PHST- 2010/02/23 00:00 [accepted]
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PHST- 2011/05/01 00:00 [pmc-release]
AID - 10.1007/s00213-010-1818-7 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2010 May;210(1):75-83. doi: 10.1007/s00213-010-1818-7. 
      Epub 2010 Mar 23.